Gut microbiome prediction of MCI conversion in German elderly
1 sample from a healthy elderly control in Germany, part of a longitudinal study of 100 healthy controls tracking gut microbiome changes predictive of progression from normal cognition to mild cognitive impairment over 4 years. machine-written summary
1 samples · 1 runs · DE · Age unknown · 2025 · 3.45 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1 sample values (country) |
| ✓ Abstract / description | 2 sample values (health condition, health condition detail) |
| ✓ Full text | 2 sample values (collection date, location site) · PMC12112180 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
Schedule stated by the source: “Same healthy controls sampled at baseline, 1-year follow-up (1yFU), and 4-year follow-up (4yFU)” (time origin: baseline/enrolment); stated follow-up 4.0 y.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 1 | 100% | ||||
| country | 1 | 100% | 1 | |||
| health_condition | 1 | 100% | 1 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 1 | 100% | 1 | |||
| detailed_location | 1 | 100% | ||||
| health_condition_detail | 1 | 100% | 1 | |||
| location_site | 1 | 100% | 1 |
- Prognostic Value of a Multivariate Gut Microbiome Model for Progression from Normal Cognition to Mild Cognitive Impairment Within 4 Years. 2025 PMID 40429881 PMC12112180 own_data
Archive description
Dysbiosis of the gut microbiome has been linked to the pathogenesis of Alzheimer`s disease (AD). How-ever, little is known about the longitudinal changes in the gut microbiome and its prognostic significance in early stages of AD, particularly in healthy individuals (HCs) who later develop mild cognitive impair-ment (MCI). Therefore, we investigated the ability of taxonomic and functional gut microbiome data from 100 HCs to predict the progression from normal cognition to MCI over a 4-year follow-up period (4yFU). Logistic regression models were built with baseline features that best discriminated between the two groups using an ANOVA type statistic. The best model for the discrimination of MCI converters was based on functional data using Gene Ontology (GO), which included 14 features. This model achieved an area under the receiver operating characteristic curve (AUROC) of 0.84 at baseline, 0.78 at 1-year follow-up (1yFU), and 0.75 at 4yFU. This functional model outperformed the taxonomic model, which included 38 genera features, in terms of descriptive performance and showed comparable efficacy to combined anal-yses integrating functional, taxonomic, and clinical characteristics. Gut microbiome algorithms have the potential to predict MCI conversion in HCs over a 4-year period, offering a promising innovative supplement for early AD prognosis.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.62. Assay shotgun_dna.
- host run.scientific_name · “Homo sapiens”
- body site study.title · “Prognostic value of gut microbiome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA118775003 | collection_date | 2016/2018 | R3 | 0.70 | paper.fulltext.methods | Tübingen (Germany) starting from 2016 to end of 2018 |
| SAMEA118775003 | country | DE | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Germany |
| SAMEA118775003 | health_condition | healthy_control | R4 | 0.50 | paper.abstract | 100 healthy controls (HC) |
| SAMEA118775003 | health_condition_detail | Healthy controls at baseline; longitudinal follow-up for MCI progression | R4 | 0.50 | paper.abstract | 100 healthy controls (HC) |
| SAMEA118775003 | location_site | Section of Dementia Research, Department of Psychiatry and Psychotherapy, Tübingen | R3 | 0.70 | paper.fulltext.methods | recruited at the Section of Dementia Research at the Department of Psychiatry |
Sequencing
1 runs over 1 samples · mean 3.45 Gbp per run (median 3.45 Gbp, total 3.45 Gbp; 1 runs with a base count) · layout PAIRED 1 · platform ILLUMINA 1 · models unspecified (1) · 0% of runs with a Sandpiper profile · first public 2025-07-30
Authors (10)
Bauch A first · Baur J · Honold I · Willmann M · Weber GL · Müller S · Sodenkamp S · Peter S · Schoppmeier U · Laske C last
Downloads
PRJEB85717.csv.gz (989 B) · parquet (70.2 KB) — all 1 samples, every field with route and confidence · PRJEB85717_determinations.csv.gz (717 B) — 5 evidence rows