UK gut microbiome in colorectal cancer detection, cross-sectional
1970 stool samples from adults undergoing colonoscopy across UK centres, examining gut microbiome associations with colorectal health and early colorectal cancer detection in this cross-sectional study. machine-written summary
1,970 samples · 1,970 runs · GB · Adult · 2026 · 2.88 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 9,850 sample values (country, latitude, location region, longitude, subject id) |
| ✓ Abstract / description | 1,970 sample values (health condition detail) |
| ✓ Full text | 1,970 sample values (collection date) · PMC13629894 |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
45 of 1,925 people sampled more than once (90 samples; median 2, up to 2 per person).
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 1,970 | 100% | ||||
| country | 1,970 | 100% | 1,970 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 1,970 | 100% | 1,970 | |||
| collection_date | 1,970 | 100% | 1,970 | |||
| detailed_location | 1,970 | 100% | ||||
| health_condition_detail | 1,970 | 100% | 1,970 | |||
| latitude | 1,970 | 100% | 1,970 | |||
| location_region | 1,970 | 100% | 1,970 | |||
| longitude | 1,970 | 100% | 1,970 |
- Baseline characteristics of participants recruited into the COLO-COHORT study: a UK-wide resource for colorectal cancer prevention. 2026 PMID 42823104 PMC13629894 own_data
Archive description
The COLO-COHORT study, a multi-centre, UK-based observational study led by Newcastle University, investigates the gut microbiome’s role in colorectal health and disease to enhance colorectal cancer prevention and early detection. A subset of participants (adults ≥18 years) from a broader cohort undergoing colonoscopy provided stool samples prior to bowel preparation, collected using a faecal immunochemical test kit (OC Sensor, Mast Diagnostics) and processed in two batches for high-throughput shotgun metagenomic sequencing. Comprehensive phenotyping, including colonoscopic findings, alongside detailed clinical and lifestyle metadata, supports research into disease mechanisms and non-invasive screening tools for colorectal neoplasia and CRC.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “COLO-COHORT: Exploring Gut Microbiome Associations of”
- body site study.description · “University, investigates the gut microbiome’s role in”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.description · “of participants ( adults ≥18 years) from”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA118657230 | collection_date | 2020-01/2024-07 | R3 | 0.70 | paper.body.methods_results | took place between 1 January 2020 and 31 July 2024 |
| SAMEA118657230 | country | GB | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | United Kingdom |
| SAMEA118657230 | health_condition_detail | mixed_case_control: colorectal health vs colorectal neoplasia/CRC | R4 | 0.40 | study.description | colorectal health and disease |
| SAMEA118657230 | latitude | 54.9796 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 54.979608 -1.621687 |
| SAMEA118657230 | location_region | England | R1 | 0.60 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 54.979608 -1.621687 |
| SAMEA118657230 | longitude | -1.6217 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 54.979608 -1.621687 |
| SAMEA118657230 | subject_id | CCA1010334 | R1 | 0.70 | sample.name_rule:alias | CCA1010334.1 |
Sequencing
1,970 runs over 1,970 samples · mean 2.92 Gbp per run (median 2.88 Gbp, total 5,756.47 Gbp; 1,970 runs with a base count) · layout PAIRED 1,970 · platform ILLUMINA 1,970 · models Illumina NovaSeq X Plus (1,970) · 0% of runs with a Sandpiper profile · first public 2026-06-22
Authors (0)
No author record.
Downloads
PRJEB91658.csv.gz (46.0 KB) · parquet (149.3 KB) — all 1,970 samples, every field with route and confidence · PRJEB91658_determinations.csv.gz (86.6 KB) — 13,790 evidence rows