Gut microbiome in UK adult twins
211 fecal samples from adult twins in the United Kingdom (TwinsUK registry), studying genetic and environmental influences on gut microbiome composition and function, using a case-control design. machine-written summary
211 samples · 211 runs · GB · Adult · 2017 · 3.84 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 844 sample values (collection date, country, latitude, longitude) |
| ✓ Abstract / description | 211 sample values (health condition detail) |
| ○ Full text | read; no usable statement or table · PMC10777373, PMC11381545, PMC11423519, PMC12084026, PMC6134768, PMC6309625, PMC6749991, PMC6894816, PMC6961876, PMC7001586, PMC8173911, PMC8907173, PMC9445621 |
| ✓ Supplementary tables | 211 sample values (health condition) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
twins — not resolved
Stool from British twins (TwinsUK); twin-pair and zygosity table in PMC6134768 uses IDs that do not join to archive samples.
Genera, mean relative abundance over 187 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 211 | 100% | ||||
| country | 211 | 100% | 211 | |||
| health_condition | 211 | 100% | 211 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 211 | 100% | 211 | |||
| health_condition_detail | 211 | 100% | 211 | |||
| latitude | 211 | 100% | 211 | |||
| longitude | 211 | 100% | 211 |
- Shotgun Metagenomics of 250 Adult Twins Reveals Genetic and Environmental Impacts on the Gut Microbiome. 2016 PMID 27818083 PMC6309625 own_data
- A metagenome-wide association study of gut microbiota in asthma in UK adults. 2018 PMID 30208875 PMC6134768 own_data
- Sharing of gut microbial strains between selected individual sets of twins cohabitating for decades. 2019 PMID 31805145 PMC6894816 own_data
- Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine. 2019 PMID 32083024 PMC7001586 own_data
- Dysbiosis of the gut microbiome is a risk factor for osteoarthritis in older female adults: a case control study. 2021 PMID 34082693 PMC8173911 own_data
8 more
- Collective effects of human genomic variation on microbiome function. 2022 PMID 35264618 PMC8907173
- Adaptive Evolution within Gut Microbiomes of Healthy People. 2019 PMID 31028005 PMC6749991
- Biogeographic study of human gut-associated crAssphage suggests impacts from industrialization and recent expansion. 2020 PMID 31940321 PMC6961876
- Open pangenome of Lactococcus lactis generated by a combination of metagenome-assembled genomes and isolate genomes. 2022 PMID 36081802 PMC9445621
- Codiversification of gut microbiota with humans. 2022 PMID 36108023 PMC10777373
- Transient colonizing microbes promote gut dysbiosis and functional impairment. 2024 PMID 39245657 PMC11381545
- A realistic benchmark for differential abundance testing and confounder adjustment in human microbiome studies. 2024 PMID 39322959 PMC11423519
- Microbes with higher metabolic independence are enriched in human gut microbiomes under stress. 2025 PMID 40377187 PMC12084026
Archive description
KCL_twins2
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site external_curation.infant_catalog · “body_site_call stool”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA4525015 | collection_date | 2010/2012 | R1 | 0.90 | biosample.attribute:collection_date | 2010/2012 |
| SAMEA4525015 | country | GB | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | United Kingdom |
| SAMEA4525015 | health_condition | healthy_control | R2 | 0.75 | paper.supp.Table_1.xlsx[c) All Samples!Diagnosis] | HEALTHY |
| SAMEA4525015 | health_condition_detail | mixed_case_control: asthma patients vs healthy controls; migraine patients vs healthy controls | R4 | 0.40 | paper.abstract | individuals with asthma and healthy controls |
| SAMEA4525015 | latitude | 51.5000 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 51.5 -0.12 |
| SAMEA4525015 | longitude | -0.1200 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 51.5 -0.12 |
Sequencing
211 runs over 211 samples · mean 3.86 Gbp per run (median 3.84 Gbp, total 815.29 Gbp; 211 runs with a base count) · layout PAIRED 211 · platform ILLUMINA 211 · models Illumina HiSeq 2000 (211) · 89% of runs with a Sandpiper profile · first public 2017-08-01
Authors (50)
Wang Q first · Li F · Liang B · Liang Y · Chen S · Mo X · Ju Y · Zhao H · Jia H · Spector TD · Xie H · Guo R last · Chen J first · Wang A · Lin Z last · Zhai Y first · Wei C last · Suzuki TA first · Fitzstevens JL · Schmidt VT · Enav H · Huus KE · Mbong Ngwese M · Grießhammer A · Pfleiderer A · Adegbite BR · Zinsou JF · Esen M · Velavan TP · Adegnika AA · Song LH · Muehlbauer AL · Marchi N · Kang H · Maier L · Blekhman R · Ségurel L · Ko G · Youngblut ND · Kremsner P · Ley RE last · Wirbel J first · Essex M · Forslund SK · Zeller G last · Schroer HW first · Beghini F · Raygoza Garay JA · Christakis NA · Bosch DE last
Downloads
PRJEB9584.csv.gz (5.7 KB) · parquet (77.6 KB) — all 211 samples, every field with route and confidence · PRJEB9584_determinations.csv.gz (7.0 KB) — 1,266 evidence rows