14-strain probiotic in healthy UK adults, single-arm trial
82 fecal samples from healthy adults (n=41) in Manchester, United Kingdom, in a single-arm open-label trial assessing gut microbiome changes after 8 weeks of 14-strain probiotic supplementation. machine-written summary
82 samples · 82 runs · GB · Adult · 2024 · 13.76 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 656 sample values (collection date, country, latitude, location locality, location region, longitude, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 164 sample values (health condition, health condition detail) · PMC10570534 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Probiotic (live microorganisms; single strain or mixture) design single_arm_before_after · population healthy_control · 14-strain probiotic blend, 8 billion CFU/day, 8 weeks, single arm
“consumed 4 capsules daily of the 14 strain blend” — abstract:37841999 (study level; per-sample arms are in the intervention column below)
longitudinal
41 of 41 people sampled more than once (82 samples; median 2, up to 2 per person) · follow-up median 56 d (max 56 d) · median interval between samples 56 d (time from visit codes mapped to the stated schedule). Schedule stated by the source: “Stool collected at baseline (Day 0) and end of study (Day 56 ± 2 days)” (time origin: intervention_start); stated follow-up 56 d.
Each row is one person (36 shown of 41); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 69 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 82 | 100% | ||||
| country | 82 | 100% | 82 | |||
| health_condition | 82 | 100% | 82 | |||
| subject_id | 82 | 100% | 82 | |||
| collection_date | 82 | 100% | 82 | |||
| detailed_location | 82 | 100% | ||||
| health_condition_detail | 82 | 100% | 82 | |||
| latitude | 82 | 100% | 82 | |||
| location_locality | 82 | 100% | 82 | |||
| location_region | 82 | 100% | 82 | |||
| longitude | 82 | 100% | 82 | |||
| timepoint_label | 82 | 100% | 82 |
- An insight into the functional alterations in the gut microbiome of healthy adults in response to a multi-strain probiotic intake: a single arm open label trial. 2023 PMID 37841999 PMC10570534 own_data
Archive description
The present, single arm, open label clinical trial, evaluated compositional and functional changes in the gut microbiome of healthy adults after 14 strain probiotic supplementation by high-throughput molecular approaches.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “alterations in the gut microbiome of healthy”
- body site study.description · “changes in the gut microbiome of healthy”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.title · “microbiome of healthy adults in response to”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN36864701 | collection_date | 2021-02-12 | R1 | 0.90 | biosample.attribute:collection_date | 2021-02-12 |
| SAMN36864701 | country | GB | R1 | 0.90 | sample.attr.geo_loc_name | United Kingdom: Manchester |
| SAMN36864701 | health_condition | healthy_control | R3 | 0.60 | paper.fulltext.results | 41 healthy young adults were enrolled in this open-label study |
| SAMN36864701 | health_condition_detail | healthy adults | R3 | 0.60 | paper.fulltext.results | 41 healthy young adults were enrolled in this open-label study |
| SAMN36864701 | latitude | 53.4812 | R1 | 0.90 | biosample.attribute:lat_lon | 53.4812 N 2.2424 W |
| SAMN36864701 | location_locality | Manchester | R1 | 0.85 | biosample.attribute:geo_loc_name | United Kingdom: Manchester |
| SAMN36864701 | location_region | England | R1 | 0.60 | biosample.attribute:lat_lon | 53.4812 N 2.2424 W |
| SAMN36864701 | longitude | -2.2424 | R1 | 0.90 | biosample.attribute:lat_lon | 53.4812 N 2.2424 W |
| SAMN36864701 | subject_id | 1-01 | R1 | 0.70 | sample.name_rule:TITLE | TITLE: Subject ID 1-01, Baseline |
| SAMN36864701 | timepoint_label | Baseline | R1 | 0.70 | sample.name_rule:TITLE | TITLE: Subject ID 1-01, Baseline |
Sequencing
82 runs over 82 samples · mean 13.57 Gbp per run (median 13.76 Gbp, total 1,112.37 Gbp; 82 runs with a base count) · layout PAIRED 82 · platform ILLUMINA 82 · models Illumina NovaSeq 6000 (82) · 84% of runs with a Sandpiper profile · first public 2024-12-29
Authors (10)
Rodenes-Gavidia A first · Lamelas A · Bloor S · Hobson A · Treadway S · Haworth J · Vijayakumar V · Naghibi M · Day R · Chenoll E last
Downloads
PRJNA1002850.csv.gz (3.0 KB) · parquet (73.9 KB) — all 82 samples, every field with route and confidence · PRJNA1002850_determinations.csv.gz (6.0 KB) — 820 evidence rows