Gut microbiota in NK/T-cell lymphoma, Korean cohort
N=41 samples from adult patients with NK/T-cell lymphoma in Seoul, Korea. Cross-sectional shotgun metagenomic study validating Chinese cohort findings on microbiota dysbiosis and *Faecalibacterium prausnitzii* association with disease outcomes. machine-written summary
41 samples · 41 runs · KR · Adult · 2023 · 2.33 Gbp / sample · cohort Clinical Impact of Microbiome Characteristics in T
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 123 sample values (collection date, country, location region) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 41 sample values (subject id) · PMC12013593, PMC12016819 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| ✓ External resources | 123 sample values (antibiotic exposure, health condition, health condition detail) · from BugSigDB, GMrepo v3 |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 37 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 41 | 100% | ||||
| country | 41 | 100% | 41 | |||
| health_condition | 41 | 100% | 41 | |||
| subject_id | 41 | 100% | 41 | |||
| antibiotic_exposure | 41 | 100% | 41 | |||
| collection_date | 41 | 100% | 41 | |||
| detailed_location | 41 | 100% | ||||
| health_condition_detail | 41 | 100% | 41 | |||
| location_region | 41 | 100% | 41 |
- Butyrate-producing Faecalibacterium prausnitzii suppresses natural killer/T-cell lymphoma by dampening the JAK-STAT pathway. 2025 PMID 39653411 PMC12013593 own_data
- Clinical Impact of Microbiome Characteristics in Treatment-Naïve Extranodal NK/T-Cell Lymphoma Patients. 2025 PMID 39164084 PMC12016819 unsure
Archive description
ENKTL shotgun metagenome
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site external_curation.infant_catalog · “body_site_call gut”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN38338532 | antibiotic_exposure | no | R2 | 0.60 | external.bugsigdb source | Antibiotics exclusion: 2 weeks |
| SAMN38338532 | collection_date | 2020-02-14 | R1 | 0.90 | biosample.attribute:collection_date | 2020-02-14 |
| SAMN38338532 | country | KR | R1 | 0.90 | sample.attr.geo_loc_name | Korea: Seoul |
| SAMN38338532 | health_condition | neurological_psychiatric | R2 | 0.75 | external.gmrepo source | phenotype: Parkinson Disease |
| SAMN38338532 | health_condition_detail | Parkinson Disease | R2 | 0.75 | external.gmrepo source | phenotype: Parkinson Disease |
| SAMN38338532 | location_region | Seoul | R1 | 0.85 | biosample.attribute:geo_loc_name | Korea: Seoul |
| SAMN38338532 | subject_id | SAMN38338532 | R3 | 0.75 | design.one_sample_per_subject:fulltext | We performed a cross-sectional study involving treatment-naïve NKTCL patients and matched healthy individuals |
Sequencing
41 runs over 41 samples · mean 2.36 Gbp per run (median 2.33 Gbp, total 96.64 Gbp; 41 runs with a base count) · layout PAIRED 41 · platform ILLUMINA 41 · models Illumina MiSeq (41) · 90% of runs with a Sandpiper profile · first public 2023-11-23 – 2023-11-24
Authors (25)
Yoon SE first · Kang W · Cho J · Chalita M · Lee JH · Hyun DW · Kim H · Kim SJ · Kim WS last · Shi Z first · Li M · Zhang C · Li H · Zhang Y · Zhang L · Li X · Li L · Wang X · Fu X · Sun Z · Zhang X · Tian L · Zhang M · Chen WH · Li Z last
Downloads
PRJNA1043252.csv.gz (2.1 KB) · parquet (71.6 KB) — all 41 samples, every field with route and confidence · PRJNA1043252_determinations.csv.gz (3.3 KB) — 287 evidence rows