Gut microbiota in Saudi children with ulcerative colitis
Cross-sectional shotgun metagenomic study of 84 samples from children in Saudi Arabia (45 with ulcerative colitis, 39 healthy controls), examining gut microbiota dysbiosis associated with the condition. machine-written summary
84 samples · 84 runs · SA · Child · 2024 · 3.20 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 504 sample values (collection date, country, health condition, health condition detail, latitude, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 168 sample values (antibiotic exposure, location locality) · PMC11804965, PMC11804967, PMC12352812 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 42 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 84 | 100% | ||||
| country | 84 | 100% | 84 | |||
| health_condition | 84 | 100% | 84 | |||
| subject_id | 0 | 0% | ||||
| antibiotic_exposure | 84 | 100% | 84 | |||
| collection_date | 84 | 100% | 84 | |||
| detailed_location | 84 | 100% | ||||
| health_condition_detail | 84 | 100% | 84 | |||
| latitude | 84 | 100% | 84 | |||
| location_locality | 84 | 100% | 84 | |||
| longitude | 84 | 100% | 84 |
- Gut fungal profile in new onset treatment-naïve ulcerative colitis in Saudi children. 2025 PMID 39523762 PMC11804965 cites_accession
- Bacterial dysbiosis in newly diagnosed treatment naïve pediatric ulcerative colitis in Saudi Arabia. 2025 PMID 38708883 PMC11804967 own_data
- Gut virome profile in new onset treatment naïve Saudi children with ulcerative colitis. 2025 PMID 40223739 PMC12352812 own_data
Archive description
In view of the emerging condition and lack of information on the role of microbiota in Saudi Arabia, shotgun metagenomic sequencing was used to describe the Microbiota in Saudi Children with Ulcerative Colitis. Microbial dysbiosis was demonstrated in this population and microbiota signature was identified. Results are preliminary and further studies with large sample size are needed.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of child by sonnet_x2 with confidence 0.68. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site study.title · “Microbiota Profile in Saudi Children with Ulcerative Colitis”
- life stage study.title · “Saudi Children with Ulcerative Colitis”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN38350056 | antibiotic_exposure | no | R3 | 0.70 | paper.body.methods | no antibiotic exposure at least 6 months before sample collection |
| SAMN38350056 | collection_date | 2022/2023 | R1 | 0.90 | biosample.attribute:collection_date | 2022/2023 |
| SAMN38350056 | country | SA | R1 | 0.90 | sample.attr.geo_loc_name | Saudi Arabia |
| SAMN38350056 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:host_disease | CeD32ST_S63_Control |
| SAMN38350057 | health_condition | healthy_control | R1 | 0.90 | biosample_attr | CeD41ST_S64_Control |
| SAMN38350056 | health_condition_detail | CeD32ST_S63_Control | R1 | 0.90 | sample.attr.host_disease | CeD32ST_S63_Control |
| SAMN38350056 | latitude | 24.7500 | R1 | 0.90 | biosample.attribute:lat_lon | 24.75 N 46.86 E |
| SAMN38350056 | location_locality | Riyadh | R3 | 0.70 | paper.body.methods | King Saud University in Riyadh, Kingdom of Saudi Arabia |
| SAMN38350056 | longitude | 46.8600 | R1 | 0.90 | biosample.attribute:lat_lon | 24.75 N 46.86 E |
Sequencing
84 runs over 84 samples · mean 3.45 Gbp per run (median 3.20 Gbp, total 290.21 Gbp; 84 runs with a base count) · layout PAIRED 84 · platform ILLUMINA 84 · models Illumina NovaSeq 6000 (84) · 71% of runs with a Sandpiper profile · first public 2024-11-08 – 2024-12-01
Authors (0)
No author record.
Downloads
PRJNA1043691.csv.gz (3.4 KB) · parquet (74.3 KB) — all 84 samples, every field with route and confidence · PRJNA1043691_determinations.csv.gz (6.2 KB) — 672 evidence rows