Hypothyroidism in early pregnancy gut metagenome, China
Shotgun metagenomic sequencing of 12 stool samples from pregnant women in Henan, China, comparing hypothyroidism cases and normal controls in a case-control design to characterize gut microbiota profiles. machine-written summary
12 samples · 12 runs · CN · Adult · 2023 · 6.10 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 84 sample values (age, collection date, country, health condition, health condition detail, location region, sex) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 36 sample values (antibiotic exposure, location site, subject id) · PMC11341541 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 12 | 100% | ||||
| country | 12 | 100% | 12 | |||
| health_condition | 12 | 100% | 12 | |||
| subject_id | 12 | 100% | 12 | |||
| age_at_collection_days | 12 | 100% | 12 | |||
| antibiotic_exposure | 12 | 100% | 12 | |||
| collection_date | 12 | 100% | 12 | |||
| detailed_location | 12 | 100% | ||||
| health_condition_detail | 12 | 100% | 12 | |||
| location_region | 12 | 100% | 12 | |||
| location_site | 12 | 100% | 12 | |||
| sex | 12 | 100% | 12 |
- Gut microbiome characteristics of women with hypothyroidism during early pregnancy detected by 16S rRNA amplicon sequencing and shotgun metagenomic. 2024 PMID 39185088 PMC11341541 own_data
Archive description
60 pregnant women (30 with hypothyroidism and 30 normal controls) were recruited for 16SrRNA gene sequencing, and 6 cases from each group were randomly selected for metagenomic sequencing to assess the gut microbiota profile.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.72. Assay shotgun_dna.
- host run.scientific_name · “Homo sapiens”
- body site study.title · “Gut Microbiome Characteristics”
- life stage study.description · “60 pregnant women”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN38354799 | age_at_collection_days | 12053.2 | R1 | 0.70 | sample.attr.age | 33 |
| SAMN38354799 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | received antibiotic, probiotic, or immunosuppressant treatment in the previous 2 months |
| SAMN38354799 | collection_date | 2022-01 | R1 | 0.90 | biosample.attribute:collection_date | 2022-01 |
| SAMN38354799 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Henan |
| SAMN38354799 | health_condition | other_disease | R1 | 0.85 | biosample.attribute:title | hypothyroidism_group |
| SAMN38354799 | health_condition_detail | hypothyroidism_group | R1 | 0.85 | biosample.attribute:title | hypothyroidism_group |
| SAMN38354799 | location_region | Henan | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Henan |
| SAMN38354799 | location_site | Third Affiliated Hospital of Zhengzhou University | R3 | 0.70 | paper.fulltext.methods | perinatal care at the Third Affiliated Hospital of Zhengzhou University |
| SAMN38354799 | sex | female | R1 | 0.90 | sample.attr.sex | female |
| SAMN38354799 | subject_id | SAMN38354799 | R3 | 0.70 | design.one_sample_per_subject:fulltext | 6 patients from each group were randomly selected for metagenomic sequencing |
Sequencing
12 runs over 12 samples · mean 6.09 Gbp per run (median 6.10 Gbp, total 73.02 Gbp; 12 runs with a base count) · layout PAIRED 12 · platform DNBSEQ 12 · models DNBSEQ-T7 (12) · 0% of runs with a Sandpiper profile · first public 2023-11-24
Downloads
PRJNA1043851.csv.gz (1.3 KB) · parquet (71.3 KB) — all 12 samples, every field with route and confidence · PRJNA1043851_determinations.csv.gz (1.9 KB) — 120 evidence rows