Gut microbiota in older adults with sarcopenia, Hong Kong
51 fecal samples from older adults in Hong Kong, comparing gut microbiota and metabolites between those with and without sarcopenia; cross-sectional design. machine-written summary
51 samples · 51 runs · HK · Adult · 2024 · 10.59 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 306 sample values (collection date, country, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 51 sample values (subject id) · PMC12073917 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
design non_randomized_controlled · FMT from human donors to antibiotic-treated mice; Lacticaseibacillus/Faecalibacterium probiotics in aged mice
Genera, mean relative abundance over 48 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 51 | 100% | ||||
| country | 51 | 100% | 51 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 51 | 100% | 51 | |||
| collection_date | 51 | 100% | 51 | |||
| detailed_location | 51 | 100% | ||||
| latitude | 51 | 100% | 51 | |||
| location_locality | 51 | 100% | 51 | |||
| location_region | 51 | 100% | 51 | |||
| longitude | 51 | 100% | 51 |
- From Clinical to Benchside: Lacticaseibacillus and Faecalibacterium Are Positively Associated With Muscle Health and Alleviate Age-Related Muscle Disorder. 2025 PMID 39829204 PMC12073917 own_data
Archive description
To investigate its role in sarcopenia, we (i) compared gut microbiota and metabolite composition between older persons with and without sarcopenia, (ii) performed fecal microbiota transplantation (FMT) from human donors to antibiotic-treated mice, and (iii) identified two specific probiotics for treatment of sarcopenia in aged mice. The results showed that older persons with sarcopenia had distinctive gut microbiota characteristics, and muscle-related probiotics enhanced muscle status of aged mice through mitochondria improvement. Attention: The manuscript is under review of journal publication, please cite any data from this study after the publication of the manuscript.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “benchside: Lacticaseibacillus and Faecalibacterium are positively associated”
- body site study.description · “we (i) compared gut microbiota and metabolite”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN38766412 | collection_date | 2021-05-01 | R1 | 0.90 | biosample.attribute:collection_date | 2021-05-01 |
| SAMN38766412 | country | HK | R1 | 0.90 | sample.attr.geo_loc_name | China: Hong Kong |
| SAMN38766412 | latitude | 22.3797 | R1 | 0.90 | biosample.attribute:lat_lon | 22.3797 N 114.2022 E |
| SAMN38766412 | location_locality | Hong Kong | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Hong Kong |
| SAMN38766412 | location_region | Sha Tin | R1 | 0.60 | biosample.attribute:lat_lon | 22.3797 N 114.2022 E |
| SAMN38766412 | longitude | 114.2022 | R1 | 0.90 | biosample.attribute:lat_lon | 22.3797 N 114.2022 E |
| SAMN38766412 | subject_id | SAMN38766412 | R3 | 0.70 | design.one_sample_per_subject:fulltext | 51 older people (age 70.2 ± 5.0 years, 74.5% females) were recruited |
Sequencing
51 runs over 51 samples · mean 10.74 Gbp per run (median 10.59 Gbp, total 547.92 Gbp; 51 runs with a base count) · layout PAIRED 51 · platform ILLUMINA 51 · models Illumina NovaSeq 6000 (51) · 94% of runs with a Sandpiper profile · first public 2024-01-28
Authors (15)
Liu C first · Wong PY · Barua N · Li B · Wong HY · Zhang N · Chow SKH · Wong SH · Yu J · Ip M · Cheung WH · Duque G · Brochhausen C · Sung JJY · Wong RMY last
Downloads
PRJNA1045861.csv.gz (2.3 KB) · parquet (71.9 KB) — all 51 samples, every field with route and confidence · PRJNA1045861_determinations.csv.gz (3.3 KB) — 357 evidence rows