Gut microbiota across human lifespan in Italy
Cross-sectional study of 467 gut microbiome samples from Italy, spanning adolescent, adult, and elderly age categories, profiling gut microbiota throughout the human lifespan. machine-written summary
519 samples · 519 runs · IT · Mixed ages · 2024 · 2.03 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,920 sample values (age, collection date, country, sex) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC11019788, PMC11494892, PMC12911220, PMC13378389 |
| ✓ Supplementary tables | 52 sample values (age, sex) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 424 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 470 | 91% | ||||
| country | 519 | 100% | 519 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| sex | 516 | 99% | 467 | 49 | ||
| age_at_collection_days | 470 | 91% | 467 | 3 | ||
| collection_date | 467 | 90% | 467 |
- Severity of Depressive Symptoms by Perceived Stress and Gut Microbiota Composition: A Sex-Stratified Bayesian Approach in a Non-Clinical Sample. 2026 PMID 41700653 PMC12911220 cites_accession
- Taxonomic and metabolic development of the human gut microbiome across life stages: a worldwide metagenomic investigation. PMID 38441032 PMC11019788 curated
- Exploring the vitamin biosynthesis landscape of the human gut microbiota. PMID 39287373 PMC11494892 curated
- Taxonomic and metabolic development of the human gut microbiome across life stages: a worldwide metagenomic investigation. 2024 PMID 38441032 PMC11019788 own_data
- Fecal calprotectin and gut microbiome in a cohort without intestinal pathologies from northern Italy. 2026 PMID 42491748 PMC13378389 own_data
Archive description
Profiling the gut microbiota throughout human lifespan
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of mixed ages and infant / toddler by sonnet_x2 with confidence 0.50. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “gut metagenome”
- life stage study.title · “throughout human lifespan”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN38496787 | age_at_collection_days | 17155 | R1 | 0.80 | sample.attr.host_age | 17155 |
| SAMN56715272 | age_at_collection_days | 9861.8 | R2 | 0.85 | paper.supp.mmc2.xlsx[TableS1!Age] | Sample PRM10; Age 27 |
| SAMN38496787 | collection_date | 2021 | R1 | 0.85 | biosample.attribute:collection_date | collection_date: 2021 |
| SAMN38496787 | country | IT | R1 | 0.90 | biosample_attr | Italy |
| SAMN56715272 | country | IT | R1 | 0.90 | sample.attr.geo_loc_name | Italy |
| SAMN38496787 | sex | female | R1 | 0.90 | biosample_attr | female |
| SAMN56715272 | sex | female | R2 | 0.85 | paper.supp.mmc2.xlsx[TableS1!Sex] | Sample PRM10; Sex F |
Sequencing
519 runs over 519 samples · mean 2.09 Gbp per run (median 2.03 Gbp, total 1,084.19 Gbp; 519 runs with a base count) · layout PAIRED 519 · platform ILLUMINA 519 · models NextSeq 2000 (519) · 82% of runs with a Sandpiper profile · first public 2024-01-05 – 2026-04-02
Authors (18)
Mancabelli L first · Milani C · De Biase R · Bocchio F · Fontana F · Lugli GA · Alessandri G · Tarracchini C · Viappiani A · De Conto F · Nouvenne A · Ticinesi A · Bussolati O · Meschi T · Cecchi R · Turroni F · Ventura M last · van Sinderen D
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJNA1046438.csv.gz (14.7 KB) · parquet (91.9 KB) — all 519 samples, every field with route and confidence · PRJNA1046438_determinations.csv.gz (12.9 KB) — 1,972 evidence rows