Gut microbiome and resistome in acute leukemia chemotherapy
20 stool samples from acute leukemia patients, collected before and after chemotherapy and antibiotic treatment, in a longitudinal study of gut microbiota and antibiotic resistance genes; country not reported. machine-written summary
20 samples · 20 runs · CN · Age unknown · 2024 · 6.58 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 40 sample values (collection date, sex) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 60 sample values (health condition, health condition detail, location site) · PMC11622590 |
| ✓ Supplementary tables | 2 sample values (timepoint) |
| ✓ External resources | 20 sample values (country) · from BugSigDB |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin design single_arm_before_after · population other_cancer · Chemotherapy and antibiotics in acute leukemia, pre/post sampling
“stool samples from acute leukemia patients before and after chemotherapy and antibiotics” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
Schedule stated by the source: “Stool collected pre-chemotherapy and two weeks post-chemotherapy (+1 day window allowed if needed)” (time origin: chemotherapy start); stated follow-up 14 d.
Genera, mean relative abundance over 18 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 20 | 100% | 20 | |||
| health_condition | 20 | 100% | 20 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 20 | 100% | 20 | |||
| detailed_location | 20 | 100% | ||||
| health_condition_detail | 20 | 100% | 20 | |||
| location_site | 20 | 100% | 20 | |||
| sex | 20 | 100% | 20 | |||
| timepoint_label | 2 | 10% | 2 |
- Exploring the dynamics of gut microbiota, antibiotic resistance, and chemotherapy impact in acute leukemia patients: A comprehensive metagenomic analysis. 2024 PMID 39620486 PMC11622590 own_data
Archive description
The metagenomic sequencing of stool samples from acute leukemia patients before and after chemotherapy and antibiotics treatment.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.62. Assay shotgun_dna.
- host run.scientific_name · “Homo sapiens”
- body site study.title · “gut microbiomes and resistomes of acute leukemia”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN38760196 | collection_date | 2021-05-29 | R1 | 0.90 | biosample.attribute:collection_date | 2021-05-29 |
| SAMN38760196 | country | CN | R2 | 0.60 | external.bugsigdb source | Location of subjects: China |
| SAMN38760196 | health_condition | other_cancer | R3 | 0.60 | paper.fulltext.results | 10 patients with AL who received induction chemotherapy |
| SAMN38760196 | health_condition_detail | acute leukemia (ALL/AML) patients undergoing induction chemotherapy | R3 | 0.60 | paper.fulltext.results | 10 patients with AL who received induction chemotherapy |
| SAMN38760196 | location_site | Second Affiliated Hospital of Shantou University Medical College | R3 | 0.70 | paper.fulltext.methods | Second Affiliated Hospital of Shantou University Medical College |
| SAMN38760196 | sex | male | R1 | 0.90 | sample.attr.sex | male |
| SAMN38760196 | timepoint_label | pre | R2 | 0.80 | paper.supp.KVIR_A_2428843_SM0732.xlsx[Table S1A.!Group] | Antibiotic dosage (g）=Sample 01; Group=Pre-Chemotherapy |
Sequencing
20 runs over 20 samples · mean 6.56 Gbp per run (median 6.58 Gbp, total 131.25 Gbp; 20 runs with a base count) · layout PAIRED 20 · platform ILLUMINA 20 · models Illumina NovaSeq 6000 (20) · 90% of runs with a Sandpiper profile · first public 2024-09-02
Authors (11)
Luo Y first · Sheikh TMM · Li X · Yuan Y · Yao F · Wang M · Guo X · Wu J · Shafiq M · Xie Q · Jiao X last
Downloads
PRJNA1050658.csv.gz (1.6 KB) · parquet (71.1 KB) — all 20 samples, every field with route and confidence · PRJNA1050658_determinations.csv.gz (1.9 KB) — 122 evidence rows