SMT vs FMT intervention study in IBS-D adults, China
327 gut metagenome samples from adults (and some elderly) in China with irritable bowel syndrome (diarrhea type), comparing selective microbiota transplantation (SMT) and fecal microbiota transplantation (FMT) in an intervention study. machine-written summary
327 samples · 327 runs · CN · Adult · 2024 · 6.65 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 2,611 sample values (age, collection date, country, intervention, intervention detail, sex, subject id, timepoint) |
| ✓ Abstract / description | 654 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
Faecal microbiota transplantation Other administered intervention (see intervention_detail) design non_randomized_controlled · population ibs · Selective microbiota transplantation (SMT) vs fecal microbiota transplantation (FMT)
“selective microbiota transplantation (SMT) and fecal microbiota transplantation” — bioproject.description (study level; per-sample arms are in the intervention column below)
sex differs between samples of the same subject id (1 subjects, 5 samples) — sex withheld.
The sources disagree on 5 samples. Where two incompatible values exist for one sample (or one person's samples disagree on sex), neither value is published: the field is left empty here, in the sample sheet and in the downloads. Both sides, with their sources, are in gut_metadata_contradictions.parquet of the data package (what counts as a contradiction).
Contradicted values (5)
| sample | field | value | other value | handling |
|---|---|---|---|---|
| SAMN39098844 | sex | male (sequence archive) | subject FMT-014: female in 4 samples, male in 1 sample | withheld: neither value published |
| SAMN39098845 | sex | female (sequence archive) | subject FMT-014: female in 4 samples, male in 1 sample | withheld: neither value published |
| SAMN39098846 | sex | female (sequence archive) | subject FMT-014: female in 4 samples, male in 1 sample | withheld: neither value published |
| SAMN39098847 | sex | female (sequence archive) | subject FMT-014: female in 4 samples, male in 1 sample | withheld: neither value published |
| SAMN39098848 | sex | female (sequence archive) | subject FMT-014: female in 4 samples, male in 1 sample | withheld: neither value published |
longitudinal
65 of 70 people sampled more than once (322 samples; median 5, up to 5 per person) · follow-up median 3 mo (max 5 mo) · median interval between samples 23 d (time from collection dates). Schedule stated by the source: “timepoints labeled 0, 2, 4, 8, 12 (unit not stated in supplied fields)”.
Each row is one person (36 shown of 65); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 306 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 327 | 100% | ||||
| country | 327 | 100% | 327 | |||
| health_condition | 327 | 100% | 327 | |||
| subject_id | 327 | 100% | 327 | |||
| age_at_collection_days | 327 | 100% | 327 | |||
| collection_date | 327 | 100% | 327 | |||
| health_condition_detail | 327 | 100% | 327 | |||
| intervention | 327 | 100% | 327 | |||
| intervention_detail | 327 | 100% | 327 | |||
| timepoint_label | 327 | 100% | 327 | |||
| sex | 322 | 98% | 322 |
Archive description
To compare the efficacy, microbiota and metabolite characteristics of selective microbiota transplantation (SMT) and fecal microbiota transplantation (FMT) in the treatment of diarrhea type irritable bowel syndrome (IBS-D)
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.72. Assay shotgun_dna.
- host run.scientific_name · “Homo sapiens”
- body site study.description · “fecal microbiota transplantation (FMT)”
- life stage sample.attr.age · “33 (n=301/327)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN39098828 | age_at_collection_days | 13149.0 | R1 | 0.85 | sample.attr.age | 36 |
| SAMN39098828 | collection_date | 2021-01-11 | R1 | 0.90 | biosample.attribute:collection_date | 2021-01-11 |
| SAMN39098828 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMN39098828 | health_condition | ibs | R4 | 0.50 | study.description | diarrhea type irritable bowel syndrome (IBS-D) |
| SAMN39098828 | health_condition_detail | IBS-D (diarrhea-predominant IBS) | R4 | 0.50 | study.description | diarrhea type irritable bowel syndrome (IBS-D) |
| SAMN39098828 | intervention | fmt | R1 | 0.90 | biosample.attribute:treatment | treatment: FMT |
| SAMN39098828 | intervention_detail | fecal microbiota transplantation arm | R1 | 0.90 | biosample.attribute:treatment | treatment: FMT |
| SAMN39098828 | sex | male | R1 | 0.90 | sample.attr.sex | male |
| SAMN39098828 | subject_id | FMT-003 | R1 | 0.85 | biosample.attribute:isolate | FMT-003 |
| SAMN39098828 | timepoint_label | 0 | R1 | 0.70 | sample.name_rule:library_names | FMT-003-0 |
Sequencing
327 runs over 327 samples · mean 6.82 Gbp per run (median 6.65 Gbp, total 2,229.14 Gbp; 327 runs with a base count) · layout PAIRED 327 · platform ILLUMINA 327 · models Illumina Genome Analyzer (327) · 94% of runs with a Sandpiper profile · first public 2024-01-10
Authors (0)
No author record.
Downloads
PRJNA1056456.csv.gz (10.5 KB) · parquet (84.2 KB) — all 327 samples, every field with route and confidence · PRJNA1056456_determinations.csv.gz (21.4 KB) — 3,265 evidence rows