Neonatal gut microbiota, delivery mode and GDM, China
Cross-sectional study of 68 neonatal gut samples from three sites in China (Hulun Buir, Enshi, Hohhot), examining how delivery mode and maternal gestational diabetes shape the initial gut microbiota. machine-written summary
68 samples · 68 runs · CN · Infant / toddler · 2024 · 22.02 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 136 sample values (collection date, country) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 68 sample values (subject id) · PMC11390658 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 61 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 68 | 100% | 68 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 68 | 100% | 68 | |||
| collection_date | 68 | 100% | 68 |
- Delivery mode and maternal gestational diabetes are important factors in shaping the neonatal initial gut microbiota. PMID 39268487 PMC11390658 curated
Archive description
Our study highlights the important influence of maternal factors, especially the mode of delivery, on the microbial structure of the neonatal gut compared to geography. We hypothesize that key species such as Phocaeicola vulgatus are influenced by the mode of delivery, interact with specific bacteriophages, or produce different metabolic effects. These changes may have implications for the development and functional integrity of the gut in later infancy. However, we focused solely on newborns, and to explore the long-term impacts under various factors, a larger and more extended cohort would be necessary. Despite these limitations, our findings contribute to a better understanding of the early gut microbiome's composition and function, shedding light on infant growth and development processes and their interactions with maternal microbes. This knowledge holds promising implications for the prevention and intervention of childhood diseases.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and neonate and adult and child by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.title · “the neonatal initial gut microbiota”
- body site study.description · “of the neonatal gut compared to geography.”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “gut in later infancy . However, we”
- life stage study.title · “in shaping the neonatal initial gut microbiota”
- life stage study.description · “structure of the neonatal gut compared to”
- life stage study.title · “Delivery mode and maternal gestational diabetes are”
- life stage study.description · “important influence of maternal factors, especially the”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN39456997 | collection_date | 2019-05-11 | R1 | 0.85 | biosample.attribute:collection_date | collection_date: 2019-05-11 |
| SAMN39456997 | country | CN | R1 | 0.90 | biosample_attr | China: Enshi |
| SAMN39456997 | subject_id | SAMN39456997 | R3 | 0.70 | design.one_sample_per_subject:fulltext | A total of 68 stool samples collected from 34 mother-infant pairs in three cities were metagenomically sequenced |
Sequencing
68 runs over 68 samples · mean 22.67 Gbp per run (median 22.02 Gbp, total 1,541.52 Gbp; 68 runs with a base count) · layout PAIRED 68 · platform ILLUMINA 68 · models Illumina HiSeq 2500 (68) · 90% of runs with a Sandpiper profile · first public 2024-04-28
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA1065277.csv.gz (2.9 KB) · parquet (72.8 KB) — all 68 samples, every field with route and confidence · PRJNA1065277_determinations.csv.gz (2.1 KB) — 204 evidence rows