Gut microbiome in dyslipidemia, Tibetan plateau, case-control
55 fecal metagenome samples from adults in Gannan, China, comparing dyslipidemic patients and healthy controls in a high-altitude Tibetan pastoral population; case-control design. machine-written summary
55 samples · 55 runs · CN · Adult · 2024 · 7.80 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 220 sample values (collection date, country, latitude, longitude) |
| ✓ Abstract / description | 55 sample values (health condition detail) |
| ✓ Full text | 110 sample values (location locality, location region) · PMC12542731 |
| ✓ Supplementary tables | 275 sample values (age, bmi, health condition, sex, subject id) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 55 | 100% | ||||
| country | 55 | 100% | 55 | |||
| health_condition | 55 | 100% | 55 | |||
| subject_id | 55 | 100% | 55 | |||
| age_at_collection_days | 55 | 100% | 55 | |||
| bmi | 55 | 100% | 55 | |||
| collection_date | 55 | 100% | 55 | |||
| detailed_location | 55 | 100% | ||||
| health_condition_detail | 55 | 100% | 55 | |||
| latitude | 55 | 100% | 55 | |||
| location_locality | 55 | 100% | 55 | |||
| location_region | 55 | 100% | 55 | |||
| longitude | 55 | 100% | 55 | |||
| sex | 55 | 100% | 55 |
- Structural and functional characterization of gut microbiota in dyslipidemic patients from high-altitude Tibetan pastoral areas. 2025 PMID 41132557 PMC12542731 own_data
Archive description
High-altitude environments, exposing inhabitants to decreased air pressure, low temperatures, low humidity, and increased ultraviolet radiation, can cause epidemiological considerations for populations permanently residing at high-altitude, including cardiovascular diseases, pulmonary morbidities, and memory dysfunction. Studies of Tibetan population living in Lhasa, Tibet (at 3660 meters) and residents who living at moderate altitude on the Yunnan-Kweichow Plateau (1500-2000 meters) in Southwestern China indicated a high prevalence and incidence of hyperlipidemia. Gut microbiota has been suggested to modulate circulating lipids and is a potential goalkeeper of dyslipidemia. However, the compositional and functional characteristics of the gut microbiota remain unexplored. In this study, we have enrolled the indigenous inhabitants in Luqu county, Tibetan Autonomous Prefecture of Gannan (3000 meters), Gansu Province in Northwest China to detect the composition and function of the gut microbiome in patients with hyperlipidemia from plateau area.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Gut microbial characteristics of”
- body site study.description · “incidence of hyperlipidemia. Gut microbiota has been”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN39528364 | age_at_collection_days | 19358.0 | R2 | 0.80 | paper.supp.Table_1.XLSX[Table S1A. Phe!Age] | 53 |
| SAMN39528364 | bmi | 22.62 | R2 | 0.80 | paper.supp.Table_1.XLSX[Table S1A. Phe!BMI] | 22.6244898 |
| SAMN39528364 | collection_date | 2020-04-12 | R1 | 0.90 | biosample.attribute:collection_date | 2020-04-12 |
| SAMN39528364 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Gannan |
| SAMN39528364 | health_condition | healthy_control | R2 | 0.80 | paper.supp.Table_1.XLSX[Table S1G. Alpha diversity!Group] | HCs |
| SAMN39528364 | health_condition_detail | mixed_case_control: Cohort includes both dyslipidemic patients and healthy controls; not a single health condition for a | R4 | 0.50 | paper.abstract | 22 dyslipidemic patients and 33 healthy controls |
| SAMN39528364 | latitude | 36.0000 | R1 | 0.90 | biosample.attribute:lat_lon | 36.00 N 105.00 E |
| SAMN39528364 | location_locality | Luqu County | R3 | 0.70 | paper.fulltext.methods | pastoral areas in Luqu County |
| SAMN39528364 | location_region | Gannan Tibetan Autonomous Prefecture, Gansu Province | R3 | 0.70 | paper.fulltext.methods | Gannan Tibetan Autonomous Prefecture, Gansu Province |
| SAMN39528364 | longitude | 105.0000 | R1 | 0.90 | biosample.attribute:lat_lon | 36.00 N 105.00 E |
| SAMN39528364 | sex | male | R2 | 0.80 | paper.supp.Table_1.XLSX[Table S1A. Phe!Gender] | Male |
| SAMN39528364 | subject_id | Ec003 | R2 | 0.80 | paper.supp.Table_1.XLSX[Table S1A. Phe!ID] | Ec003 |
Sequencing
55 runs over 55 samples · mean 7.75 Gbp per run (median 7.80 Gbp, total 426.05 Gbp; 55 runs with a base count) · layout PAIRED 55 · platform DNBSEQ 55 · models DNBSEQ-T7 (55) · 0% of runs with a Sandpiper profile · first public 2024-01-24
Downloads
PRJNA1067529.csv.gz (3.1 KB) · parquet (74.5 KB) — all 55 samples, every field with route and confidence · PRJNA1067529_determinations.csv.gz (6.4 KB) — 660 evidence rows