Home › Studies › PRJNA1072756
PRJNA1072756 SRP487932

HSCT patients' gut microbiomes, longitudinal, Vellore, India

Enriched microbiomes from patients undergoing haematopoietic stem cell transplantation in India

262 MacConkey-enriched stool samples from adult patients undergoing allogenic or haploidentical haematopoietic stem cell transplantation at a single centre in Vellore, India, collected longitudinally. machine-written summary

262 samples · 262 runs · IN · Adult · 2024 · 3.94 Gbp / sample

Sources
✓Sequence archive 2,092✓Abstract / description 524–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive2,092 sample values (collection date, country, latitude, location locality, location region, longitude, subject id, timepoint)
✓ Abstract / description524 sample values (health condition, health condition detail)
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 sampling locations · 1 country
Age
adult262
Condition
transplant_or_immunocompromised262
Country
IN262
Body site
primary262
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)this project, 0.3–1 Gbp: 7 samplesall projects, 1–3 Gbp: 124,983 samples (22 %)this project, 1–3 Gbp: 50 samplesall projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 204 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 1 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 3.94 Gbp per sample0130Gbp
Sampling design and relatedness

longitudinal

71 of 89 people sampled more than once (242 samples; median 3, up to 7 per person) · follow-up median 35 d (max 6 mo) · median interval between samples 10 d (time from collection dates). Schedule stated by the source: “before and after transplant timepoints (e.g. BT/AT codes); specific day offsets not stated” (time origin: transplant).

0101: day 001: day 801: day 901: day 380202: day 002: day 902: day 380303: day 003: day 803: day 903: day 2803: day 340404: day 004: day 1204: day 2104: day 1020505: day 005: day 605: day 140606: day 006: day 606: day 2306: day 350707: day 007: day 907: day 191010: day 010: day 1810: day 3410: day 381111: day 011: day 911: day 111212: day 012: day 1112: day 121313: day 013: day 3713: day 1221414: day 014: day 514: day 491515: day 015: day 815: day 341717: day 017: day 617: day 331818: day 018: day 518: day 262020: day 020: day 1020: day 2820: day 3620: day 952121: day 021: day 921: day 3921: day 652222: day 022: day 922: day 1622: day 372323: day 023: day 223: day 1123: day 202424: day 024: day 3824: day 6924: day 1112525: day 025: day 1525: day 1925: day 352626: day 026: day 626: day 1126: day 2226: day 3926: day 4826: day 573434: day 034: day 734: day 834: day 934: day 1534: day 343737: day 037: day 837: day 2937: day 3337: day 4137: day 1573838: day 038: day 1138: day 1238: day 624343: day 043: day 943: day 2343: day 724444: day 044: day 944: day 3344: day 344646: day 046: day 146: day 946: day 115050: day 050: day 1450: day 2150: day 1375151: day 051: day 1151: day 2051: day 2551: day 8651: day 1305252: day 052: day 1052: day 1752: day 495353: day 053: day 853: day 1353: day 3053: day 5053: day 565454: day 054: day 1454: day 2254: day 2554: day 485555: day 055: day 955: day 1155: day 625757: day 057: day 1057: day 2157: day 2657: day 3557: day 396161: day 061: day 1061: day 3461: day 4061: day 6461: day 780 d39 d3 mo4 mo5 mo

Each row is one person (36 shown of 71); dots are samples at days since that person's first sample.

How longitudinal and relatedness information is derived

Community composition
Escherichia 53.9%Klebsiella 12.5%Enterococcus_B 9.0%Stutzerimonas 4.4%ECMA0423 3.8%Staphylococcus 1.6%Acinetobacter 1.3%Enterobacter 0.9%Proteus 0.8%Citrobacter 0.7%Morganella 0.6%Enterococcus 0.5%not assigned to a genus 5.7%other genera 4.2%

Genera, mean relative abundance over 229 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category262 100%
country262 100%262
health_condition262 100%262
subject_id260 99%260
collection_date262 100%262
detailed_location262 100%
health_condition_detail262 100%262
latitude262 100%262
location_locality262 100%262
location_region262 100%262
longitude262 100%262
timepoint_label260 99%260
Papers (2)
  • Gut translocation of antimicrobial resistant pathogens in patients undergoing haematopoietic stem cell transplantation in India 2025 own_data
  • Stool-based genomic surveillance identifies post-engraftment expansion of multidrug-resistant pathogens in haematopoietic stem cell transplant patients in India 2026 own_data
Details
Archive description

MacConkey-enriched plate-sweeps of longitudinal stool samples collected from patients undergoing allogenic or haploidentical haematopoietic stem cell transplantation at a single centre in India.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.

  • host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
  • body site study.description · “plate-sweeps of longitudinal stool samples collected from”
  • body site external_curation.infant_catalog · “body_site_call gut”
  • life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN39752622collection_date2022-06-13R10.90biosample.attribute:collection_date2022-06-13
SAMN39752622countryINR10.90sample.attr.geo_loc_nameIndia: Vellore
SAMN39752622health_conditiontransplant_or_immunocompromisedR40.50study.descriptionpatients undergoing allogenic or haploidentical haematopoietic stem cell transplantation
SAMN39752622health_condition_detailPatients undergoing haematopoietic stem cell transplantation (allogeneic or haploidentical)R40.50study.descriptionpatients undergoing allogenic or haploidentical haematopoietic stem cell transplantation
SAMN39752622latitude12.9165R10.90biosample.attribute:lat_lon12.9165 N 79.1325 E
SAMN39752622location_localityVelloreR10.85biosample.attribute:geo_loc_nameIndia: Vellore
SAMN39752622location_regionTamil NaduR10.60biosample.attribute:lat_lon12.9165 N 79.1325 E
SAMN39752622longitude79.1325R10.90biosample.attribute:lat_lon12.9165 N 79.1325 E
SAMN39752622subject_id01R10.70sample.name_rule:aliasP01BT0041
SAMN39752622timepoint_labelBT0041R10.70sample.name_rule:aliasP01BT0041
Sequencing

262 runs over 262 samples · mean 4.09 Gbp per run (median 3.94 Gbp, total 1,070.70 Gbp; 262 runs with a base count) · layout PAIRED 262 · platform ILLUMINA 262 · models Illumina NovaSeq 6000 (262) · 87% of runs with a Sandpiper profile · first public 2024-02-07

Authors (12)

Madhav A first · Jacob JJ · Selvarajan S · Kulkarni S · Murugan D · Narayanan PS · Muniyandi Y · Mohan K · Das S · George B · Veeraraghavan B · Baker S last

Downloads

PRJNA1072756.csv.gz (9.1 KB) · parquet (82.4 KB) — all 262 samples, every field with route and confidence · PRJNA1072756_determinations.csv.gz (21.4 KB) — 2,616 evidence rows

Samples (262 · every field this project has values for · hover a cell for its source)
Loading the sample table…