Gut metagenomes in schizophrenia vs bipolar disorder, Guangzhou
Case-control study of 111 fecal metagenomic samples from adults in Guangzhou, China, comparing schizophrenia (85) with healthy controls (26), examining Prevotella copri and acetate production linked to serotonin metabolism. machine-written summary
111 samples · 111 runs · CN · Adult · 2024 · 9.13 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 999 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 96 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 111 | 100% | ||||
| country | 111 | 100% | 111 | |||
| health_condition | 111 | 100% | 111 | |||
| subject_id | 111 | 100% | 111 | |||
| collection_date | 111 | 100% | 111 | |||
| detailed_location | 111 | 100% | ||||
| health_condition_detail | 111 | 100% | 111 | |||
| latitude | 111 | 100% | 111 | |||
| location_locality | 111 | 100% | 111 | |||
| location_region | 111 | 100% | 111 | |||
| longitude | 111 | 100% | 111 |
- Acetate-producing Prevotella copri aggravates schizophrenia behaviors by modulating serotonin metabolism 2025 own_data
Archive description
Background: Schizophrenia is a complex mental disorder with approximately 1% lifetime risk worldwide, while the differential diagnosis based on currently clinical criteria is still difficult. A growing literature has demonstrated the biological interactions between gut microbiome and host brain. The metagenomic features may shed the light on how the gut-brain axis works in schizophrenia.</p><p>Results: A case-control study including 111 fecal metagenomic samples was performed to selected the schizophrenia-associated microbial species and functional modules in comparison with bipolar disorder. The clinical rating scales of both mental diseases were partially explained by gut microbiome. Among these, the Prevotella copri was screened out by an integrated approach. The functional annotation and anaerobic culture further confirmed its acetate-producing ability, which was also supported by the changes in serum acetate of schizophrenia patients. Increasing both engraftment of Prevotella copri type strain or acetate intake independently induced schizophrenia-like behaviors in mice. Using transcriptomic and metabolomic analysis, the dysregulation of serotonin metabolism across colon, serum and prefrontal cortex was observed after engrafting Prevotella copri type strain. The proteins involved in biosynthesis, transportation and degradation of serotonin were significantly elevated after increasing acetate intake.</p><p>Conclusions: This study suggests that the acetate-producing Prevotella copri selected from clinical metagenome can promote schizophrenia-like behaviors in mice by modulating serotonin metabolism. Larger replication studies and further detailed molecular validation are necessary for the generalizability and future clinical applications of the schizophrenia-specific microbial features.
How this project entered the registry
Classified as human gut / stool / blood / tissue / internal fluids shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.description · “biological interactions between gut microbiome and host”
- body site external_curation.infant_catalog · “body_site_call gut”
- body site study.description · “the changes in serum acetate of schizophrenia”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN39861762 | collection_date | 2017-10-23 | R1 | 0.90 | biosample.attribute:collection_date | 2017-10-23 |
| SAMN39861762 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Guangzhou |
| SAMN39861762 | health_condition | neurological_psychiatric | R1 | 0.90 | biosample_attr | Bipolar disorder |
| SAMN39861762 | health_condition_detail | Bipolar disorder | R1 | 0.90 | sample.attr.host_disease | Bipolar disorder |
| SAMN39861762 | latitude | 23.1900 | R1 | 0.90 | biosample.attribute:lat_lon | 23.19 N 113.34 E |
| SAMN39861762 | location_locality | Guangzhou | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Guangzhou |
| SAMN39861762 | location_region | Guangdong | R1 | 0.60 | biosample.attribute:lat_lon | 23.19 N 113.34 E |
| SAMN39861762 | longitude | 113.3400 | R1 | 0.90 | biosample.attribute:lat_lon | 23.19 N 113.34 E |
| SAMN39861762 | subject_id | JSSCZ2017180001 | R1 | 0.85 | sample.attr.host_subject_id | JSSCZ2017180001 |
Sequencing
111 runs over 111 samples · mean 10.21 Gbp per run (median 9.13 Gbp, total 1,133.66 Gbp; 111 runs with a base count) · layout PAIRED 111 · platform ILLUMINA 111 · models Illumina MiSeq (111) · 86% of runs with a Sandpiper profile · first public 2024-03-21 – 2024-03-24
Authors (0)
No author record.
Downloads
PRJNA1074507.csv.gz (3.9 KB) · parquet (75.6 KB) — all 111 samples, every field with route and confidence · PRJNA1074507_determinations.csv.gz (7.1 KB) — 999 evidence rows