Gut metagenome in Cushing disease patients, China, case-control
27 gut metagenome samples from adults in China, comparing individuals with active Cushing disease to matched controls, in a case-control design examining links between gut microbial species and cortisol/cognition measures. machine-written summary
27 samples · 27 runs · CN · Adult · 2024 · 22.1 Mbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 132 sample values (collection date, country, latitude, location region, longitude) |
| ✓ Abstract / description | 27 sample values (subject id) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| ✓ External resources | 54 sample values (health condition, health condition detail) · from GMrepo v3 |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 27 | 100% | ||||
| country | 27 | 100% | 27 | |||
| health_condition | 27 | 100% | 27 | |||
| subject_id | 27 | 100% | 27 | |||
| collection_date | 27 | 100% | 27 | |||
| health_condition_detail | 27 | 100% | 27 | |||
| latitude | 27 | 100% | 27 | |||
| longitude | 27 | 100% | 27 | |||
| detailed_location | 24 | 89% | ||||
| location_region | 24 | 89% | 24 |
- Concomitant gut dysbiosis and defective gut barrier serve as the bridges between hypercortisolism and chronic systemic inflammation in Cushing's disease. 2024 PMID 39460431 own_data
Archive description
In this study, we first performed a metagenomic study in individuals with Cushing disease (CD) and age- and body mass index-matched healthy controls. We found that gut microbial composition in patients with CD was notably different from that in healthy controls. Next, we performed network analysis and revealed the core specie in the gut microbial system of CD patients, and consecutive correlation analysis exhibited the significant associations between core species and UFC. Subsequent genome interaction group (GIG) analysis identified the positive correlations between central GIG and UFC as well as impaired cognition score.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.57. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site study.description · “gut microbial composition in patients”
- life stage study.description · “age- and body mass index-matched”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN42877087 | collection_date | 2018-05 | R1 | 0.90 | biosample.attribute:collection_date | 2018-05 |
| SAMN42877087 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMN42877087 | health_condition | other_disease | R2 | 0.75 | external.gmrepo source | phenotype: Pituitary ACTH Hypersecretion |
| SAMN42877087 | health_condition_detail | Pituitary ACTH Hypersecretion | R2 | 0.75 | external.gmrepo source | phenotype: Pituitary ACTH Hypersecretion |
| SAMN42877087 | latitude | 31.1300 | R1 | 0.90 | biosample.attribute:lat_lon | 31.13 N 121.27 E |
| SAMN42877087 | location_region | Shanghai Shi | R1 | 0.60 | biosample.attribute:lat_lon | 31.13 N 121.27 E |
| SAMN42877087 | longitude | 121.2700 | R1 | 0.90 | biosample.attribute:lat_lon | 31.13 N 121.27 E |
| SAMN42877087 | subject_id | SAMN42877087 | R4 | 0.60 | design.one_sample_per_subject:abstract | Twenty-seven patients with CD and 45 healthy controls were enrolled |
Sequencing
27 runs over 27 samples · mean 82.8 Mbp per run (median 22.1 Mbp, total 2.23 Gbp; 27 runs with a base count) · layout SINGLE 27 · platform ILLUMINA 27 · models Illumina MiSeq (27) · 0% of runs with a Sandpiper profile · first public 2024-07-30
Authors (0)
No author record.
Downloads
PRJNA1080251.csv.gz (1.7 KB) · parquet (71.2 KB) — all 27 samples, every field with route and confidence · PRJNA1080251_determinations.csv.gz (2.6 KB) — 213 evidence rows