Iron intervention trial in infants, Rupganj, Bangladesh
1422 stool samples from a randomized trial of dietary supplementation (iron) in infants in Rupganj, Bangladesh, analyzed by 16S rRNA and shotgun metagenomic sequencing. machine-written summary
1,422 samples · 1,736 runs · BD · Infant / toddler · 2024 · 1.45 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 4,243 sample values (collection date, country, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 3,808 sample values (age, collection date, lifestyle, lifestyle detail) · PMC11324872, PMC11452624 |
| ✓ Supplementary tables | 2,499 sample values (antibiotic exposure, intervention, timepoint) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-microbial dietary supplement (vitamins design randomized_controlled_trial · population healthy_control · Iron supplements or iron-containing micronutrient powders vs placebo, given for 3 months
“placebo-controlled randomized controlled trial of iron or MNPs given for 3 months” — abstract:39367018 (study level; per-sample arms are in the intervention column below)
longitudinal
430 of 815 people sampled more than once (1,037 samples; median 2, up to 3 per person) · follow-up median 9 mo (max 18 mo) · median interval between samples 7 mo (time from collection dates).
Each row is one person (36 shown of 430); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 858 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 940 | 66% | ||||
| country | 1,422 | 100% | 1,422 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 1,422 | 100% | 1,422 | |||
| collection_date | 1,422 | 100% | 1,398 | 24 | ||
| lifestyle | 1,422 | 100% | 1,422 | |||
| lifestyle_detail | 1,422 | 100% | 1,422 | |||
| timepoint_label | 1,417 | 100% | 1 | 1,416 | ||
| age_at_collection_days | 940 | 66% | 940 | |||
| intervention | 789 | 55% | 789 | |||
| antibiotic_exposure | 294 | 21% | 294 |
- Community use of oral antibiotics transiently reprofiles the intestinal microbiome in young Bangladeshi children. PMID 39143045 PMC11324872 curated
- Effects of iron supplements and iron-containing micronutrient powders on the gut microbiome in Bangladeshi infants: a randomized controlled trial. PMID 39367018 PMC11452624 curated
Archive description
16S rRNA and shotgun metagenomic sequencing files from stool samples of the Benefits and Risks of Iron InterventionS in Children (BRISC) study conducted in rural Bangladesh.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and child by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.description · “sequencing files from stool samples of the”
- body site external_curation.infant_catalog · “infant triage verdict include (gut/stool scope)”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “Iron InterventionS in Children (BRISC) study conducted”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN40195430 | age_at_collection_days | 244 | R3 | 0.50 | paper.fulltext.methods | baseline – 8 months of age |
| SAMN40195439 | antibiotic_exposure | no | R2 | 0.80 | paper.supp.41467_2024_51326_MOESM4_ESM.xlsx_Figure_5A_[antibiotic1] | 2_221-85_L000: 0 |
| SAMN40195430 | collection_date | 2018-12-26 | R1 | 0.85 | biosample.attribute:collection_date | 2018-12-26 |
| SAMN40195437 | collection_date | 2018-09/2019-02 | R3 | 0.60 | paper.fulltext.results | recruited to the trial (between September 2018 and February 2019) |
| SAMN40195430 | country | BD | R1 | 0.90 | biosample_attr | Bangladesh: Rupganj |
| SAMN40195430 | intervention | placebo | R2 | 0.80 | paper.supp.41467_2024_53013_MOESM4_ESM.xlsx_Figure_1C_[treat] | 1F105R04: Placebo |
| SAMN40195430 | lifestyle | rural_non_industrialized | R3 | 0.70 | paper.fulltext.methods | living in Rupganj Upazila, Bangladesh (a rural area |
| SAMN40195430 | lifestyle_detail | Rural Bangladeshi infants (BRISC trial) | R3 | 0.70 | paper.fulltext.methods | living in Rupganj Upazila, Bangladesh (a rural area |
| SAMN40195430 | subject_id | 1F0323 | R1 | 0.70 | sample.name_rule:sample_alias | 1F0323 |
| SAMN40195473 | timepoint_label | 13;30 | R1 | 0.85 | biosample.attribute:collection_time | collection_time: 13;30 |
| SAMN40195430 | timepoint_label | Post-intervention | R2 | 0.80 | paper.supp.41467_2024_53013_MOESM4_ESM.xlsx_Figure_1D_[Rnd] | 1F105R04: Post-intervention |
Sequencing
1,736 runs over 1,422 samples · mean 1.10 Gbp per run (median 1.03 Gbp, total 1,908.23 Gbp; 1,736 runs with a base count) · layout PAIRED 1,736 · platform ILLUMINA 1,736 · models Illumina NovaSeq 6000 (944), Illumina MiSeq (792) · 49% of runs with a Sandpiper profile · first public 2024-08-07 – 2025-03-03
Authors (24)
Baldi A first · Braat S · Imrul Hasan M · Bennett C · Barrios M · Jones N · Moir-Meyer G · Abdul Azeez I · Wilcox S · Saiful Alam Bhuiyan M · Ataide R · Clucas D · Harrison LC · Arifeen SE · Bowden R · Biggs BA · Jex A · Pasricha SR last · Hasan MI · Roy PK · Bhuiyan MSA · Larson LM · Hamadani J · Zimmermann M
Downloads
PRJNA1081952.csv.gz (46.5 KB) · parquet (135.8 KB) — all 1,422 samples, every field with route and confidence · PRJNA1081952_determinations.csv.gz (84.2 KB) — 10,550 evidence rows