Gut microbiome in lactose intolerance vs controls, China
Case-control shotgun metagenomic study of 82 stool samples from lactose-intolerant individuals and healthy controls (41 each per the paper) recruited at Xiyuan Hospital, Beijing, China. machine-written summary
82 samples · 82 runs · CN · Age unknown · 2024 · 13.35 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 406 sample values (collection date, country, health condition, health condition detail, location locality) |
| ✓ Abstract / description | 82 sample values (location region) |
| ✓ Full text | 246 sample values (antibiotic exposure, location site, subject id) · PMC11494873 |
| ✓ Supplementary tables | 132 sample values (bmi, sex) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 82 | 100% | 82 | |||
| health_condition | 80 | 98% | 80 | |||
| subject_id | 82 | 100% | 82 | |||
| antibiotic_exposure | 82 | 100% | 82 | |||
| collection_date | 82 | 100% | 82 | |||
| detailed_location | 82 | 100% | ||||
| location_locality | 82 | 100% | 82 | |||
| location_region | 82 | 100% | 82 | |||
| location_site | 82 | 100% | 82 | |||
| health_condition_detail | 80 | 98% | 80 | |||
| sex | 80 | 98% | 80 | |||
| bmi | 52 | 63% | 52 |
- Gut microbiome and serum metabolome alterations associated with lactose intolerance (LI): a case‒control study and paired-sample study based on the American Gut Project (AGP). 2024 PMID 39320101 PMC11494873 own_data
Archive description
41 patients with lactose intolerance (LI) and 41 healthy controls (HC) were recruited.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by curator_audit with confidence 0.60. Assay shotgun_dna.
- host runs.scientific_name · “human gut metagenome”
- host study_title · “Gut Microbiome of Lactose Intolerant Individuals”
- body site runs.scientific_name · “human gut metagenome”
- body site study_title · “Gut Microbiome of Lactose Intolerant Individuals”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN40210187 | antibiotic_exposure | no | R3 | 0.70 | paper.body.methods | individuals who had used antibiotics, steroid hormones, or probiotics within the past 3 months |
| SAMN40210187 | bmi | 19.72 | R2 | 0.85 | paper.supp.msystems.00839-24-s0007.xlsx[Table S2!BMI] | A001 BMI 19.7210369679802 |
| SAMN40210187 | collection_date | 2021 | R1 | 0.85 | biosample.attribute:collection_date | 2021 |
| SAMN40210187 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Beijing |
| SAMN40210187 | health_condition | other_disease | R1 | 0.85 | biosample.attribute:DESCRIPTION | LI |
| SAMN40210187 | health_condition_detail | lactose intolerance (LI) | R1 | 0.85 | biosample.attribute:DESCRIPTION | LI |
| SAMN40210187 | location_locality | Beijing | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Beijing |
| SAMN40210187 | location_region | China | R4 | 0.50 | paper.abstract | performed metagenomic and untargeted metabolomic analyses in a Chinese cohort |
| SAMN40210187 | location_site | Xiyuan Hospital | R3 | 0.70 | paper.body.methods | were recruited from Xiyuan Hospital |
| SAMN40210187 | sex | female | R2 | 0.85 | paper.supp.msystems.00839-24-s0007.xlsx[Table S2!Sex] | A001 Sex Female |
| SAMN40210187 | subject_id | SAMN40210187 | R3 | 0.70 | design.one_sample_per_subject:fulltext | We initially selected the top 100 gut microbiota species based on SHAP analysis from a sample comprising 82 individuals with LI. |
Sequencing
82 runs over 82 samples · mean 13.71 Gbp per run (median 13.35 Gbp, total 1,124.56 Gbp; 82 runs with a base count) · layout PAIRED 82 · platform ILLUMINA 82 · models Illumina NovaSeq 6000 (82) · 93% of runs with a Sandpiper profile · first public 2024-08-25
Authors (0)
No author record.
Downloads
PRJNA1082417.csv.gz (3.4 KB) · parquet (74.9 KB) — all 82 samples, every field with route and confidence · PRJNA1082417_determinations.csv.gz (7.5 KB) — 866 evidence rows