Gut microbiota in T2DM with circadian disruption, China
7 stool samples from Chinese adults with type 2 diabetes and circadian rhythm disruption, comparing well- versus poorly-controlled blood glucose groups, with probiotic (Lactobacillus johnsonii) intervention testing; case-control design. machine-written summary
7 samples · 7 runs · CN · Adult · 2024 · 6.49 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 14 sample values (collection date, country) |
| ✓ Abstract / description | 14 sample values (health condition, health condition detail) |
| ✓ Full text | 14 sample values (location site, sex) · PMC13201571 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Probiotic (live microorganisms; single strain or mixture) · population type2_diabetes · Human stool metagenomics observational; L. johnsonii probiotic given to diabetic mice only
“diabetic mice with circadian rhythm disruption were administered L. johnsonii” — bioproject.description (study level; per-sample arms are in the intervention column below)
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 7 | 100% | ||||
| country | 7 | 100% | 7 | |||
| health_condition | 7 | 100% | 7 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 7 | 100% | 7 | |||
| detailed_location | 7 | 100% | ||||
| health_condition_detail | 7 | 100% | 7 | |||
| location_site | 7 | 100% | 7 | |||
| sex | 7 | 100% | 7 |
- Impact of Lactobacillus johnsonii on glycemic control and lipid metabolism in type 2 diabetes with circadian disruption. 2026 PMID 41904207 PMC13201571 own_data
Archive description
Stool samples were collected from six patients with poorly controlled type 2 diabetes mellitus (T2DM) and circadian rhythm disruption, as well as from six patients with well-controlled T2DM and circadian rhythm disruption. Metagenomic sequencing was performed on the stool samples. Compared to the well-controlled group, the abundance of Lactobacillus johnsonii was significantly decreased in the poorly controlled group. To investigate the effects of L. johnsonii supplementation on glucose and lipid metabolism, diabetic mice with circadian rhythm disruption were administered L. johnsonii and their metabolic indicators were measured.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “The effect of gut microbiota on the”
- body site study.description · “Stool samples were collected”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN40446857 | collection_date | 2023 | R1 | 0.90 | biosample.attribute:collection_date | 2023 |
| SAMN40446857 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMN40446857 | health_condition | type2_diabetes | R4 | 0.50 | paper.abstract | patients with type 2 diabetes mellitus (T2DM) and circadian rhythm disruption |
| SAMN40446857 | health_condition_detail | type 2 diabetes mellitus with circadian rhythm disruption | R4 | 0.50 | study.description | type 2 diabetes mellitus (T2DM) and circadian rhythm disruption |
| SAMN40446857 | location_site | Endocrinology Department of Hebei Engineering University Affiliated Hospital | R3 | 0.60 | paper.fulltext.results | recruited from the Endocrinology Department of Hebei Engineering University Affiliated Hospital |
| SAMN40446857 | sex | male | R3 | 0.60 | paper.fulltext.results | All recruited patients were males |
Sequencing
7 runs over 7 samples · mean 6.60 Gbp per run (median 6.49 Gbp, total 46.17 Gbp; 7 runs with a base count) · layout PAIRED 7 · platform ILLUMINA 7 · models Illumina NovaSeq 6000 (7) · 100% of runs with a Sandpiper profile · first public 2024-03-15
Authors (8)
Yan Y first · Zhen W · Hongxia S · Zhenhong S · Xianghui M · Na W · Li S · Defeng W last
Downloads
PRJNA1087526.csv.gz (1.1 KB) · parquet (70.4 KB) — all 7 samples, every field with route and confidence · PRJNA1087526_determinations.csv.gz (1.0 KB) — 42 evidence rows