Gut microbiota in craniopharyngioma patients vs controls, Beijing
30 fecal samples (case-control design) from craniopharyngioma patients and healthy controls in Beijing, China, analyzed for gut microbiota composition and metabolic patterns via metagenomic sequencing. machine-written summary
30 samples · 30 runs · CN · Adult · 2025 · 7.36 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 150 sample values (collection date, country, health condition, health condition detail, location locality) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 60 sample values (location site, subject id) · PMC11044453 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 30 | 100% | ||||
| country | 30 | 100% | 30 | |||
| health_condition | 30 | 100% | 30 | |||
| subject_id | 30 | 100% | 30 | |||
| collection_date | 30 | 100% | 30 | |||
| detailed_location | 30 | 100% | ||||
| health_condition_detail | 30 | 100% | 30 | |||
| location_locality | 30 | 100% | 30 | |||
| location_site | 30 | 100% | 30 |
- Gut microbiota composition and metabolic characteristics in patients with Craniopharyngioma. 2024 PMID 38658858 PMC11044453 own_data
Archive description
Emerging evidence suggests that the gut microbiota is associated with various intracranial neoplastic diseases. It has been observed that alterations in the gut microbiota are present in gliomas, meningiomas, and pituitary neuroendocrine tumors (Pit-NETs). However, the correlation between gut microbiota and craniopharyngioma (CP), a rare embryonic malformation tumor in the sellar region, has not been previously mentioned. Consequently, this study aimed to investigate the gut microbiota composition and metabolic patterns in CP patients, with the goal of identifying potential therapeutic approaches.</p><p>We enrolled 15 medication-free and non-operated patients with CP and 15 healthy controls (HCs), conducting sequential metagenomic on fecal samples to investigate changes in the gut microbiota of CP patients.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.57. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site study.description · “metagenomic on fecal samples”
- life stage study.description · “non-operated patients with CP”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN40657520 | collection_date | 2023-05 | R1 | 0.90 | biosample.attribute:collection_date | 2023-05 |
| SAMN40657520 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Beijing |
| SAMN40657520 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:alias | CON1 |
| SAMN40657520 | health_condition_detail | healthy control (HC) per study description | R1 | 0.70 | sample.name_rule:alias | CON1 |
| SAMN40657520 | location_locality | Beijing | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Beijing |
| SAMN40657520 | location_site | Beijing Tiantan Hospital of Capital Medical University | R3 | 0.70 | paper.fulltext.methods | recruited 15 patients with CP and 15 HCs from Beijing Tiantan Hospital |
| SAMN40657520 | subject_id | SAMN40657520 | R3 | 0.70 | design.one_sample_per_subject:fulltext | We enrolled 15 medication-free and non-operated patients with CP and 15 healthy controls (HCs) |
Sequencing
30 runs over 30 samples · mean 7.64 Gbp per run (median 7.36 Gbp, total 229.35 Gbp; 30 runs with a base count) · layout PAIRED 30 · platform ILLUMINA 30 · models Illumina NovaSeq 6000 (30) · 100% of runs with a Sandpiper profile · first public 2025-04-03 – 2025-04-27
Authors (15)
Liu C first · Liu F · Nie D · Xiao Y · Wu W · Jia Y · Jin L · Qiao N · Cai K · Ru S · Liu X · Song Y · Xu J · Cao L · Gui S last
Downloads
PRJNA1093500.csv.gz (1.8 KB) · parquet (71.6 KB) — all 30 samples, every field with route and confidence · PRJNA1093500_determinations.csv.gz (2.5 KB) — 210 evidence rows