Metagenomics in pregnant/lactating women & infants
736 gut metagenome samples from pregnant and lactating women and their infants in Hounde, Burkina Faso, from a randomized controlled trial of a dietary supplement intervention. machine-written summary
736 samples · 736 runs · BF · Infant / toddler · 2024 · 20.14 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,472 sample values (country, subject id) |
| ✓ Abstract / description | 1,472 sample values (lifestyle, lifestyle detail) |
| ○ Full text | read; no usable statement or table · PMC11920048 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-microbial dietary supplement (vitamins design randomized_controlled_trial · population pregnancy_postpartum · Balanced energy-protein supplementation during pregnancy and lactation
“Balanced energy-protein (BEP) supplementation during pregnancy” — abstract:40102379 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolvedmother–infant — not resolved
257 of 298 people sampled more than once (695 samples; median 3, up to 4 per person). Schedule stated by the source: “Repeated sampling per subject (max 4, median 2 samples/subject); titles imply multiple visits (e.g. pn12, pn56, incl) but exact timing not stated”.
Cohort of pregnant/lactating women and their infants (RCT in Burkina Faso); mother-infant relation stated but no linkage field given..
Genera, mean relative abundance over 674 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 736 | 100% | 736 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 736 | 100% | 736 | |||
| lifestyle | 736 | 100% | 736 | |||
| lifestyle_detail | 736 | 100% | 736 |
- Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: a randomized controlled trial. PMID 40102379 PMC11920048 curated
Archive description
we use deep metagenomic sequencing to characterise the composition and functionality of the gut microbiome in pregnant and lactating women and their infants within a randomised controlled trial conducted in rural Burkina Faso.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.title · “Misame3 gut metagenomic”
- body site study.description · “functionality of the gut microbiome in pregnant”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “women and their infants within a randomised”
- life stage study.description · “pregnant and lactating women and their infants”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN41447806 | country | BF | R1 | 0.90 | biosample_attr | Burkina Faso: Hounde |
| SAMN41447806 | lifestyle | rural_non_industrialized | R4 | 0.45 | ena.study_description | conducted in rural Burkina Faso |
| SAMN41447806 | lifestyle_detail | randomised controlled trial conducted in rural Burkina Faso | R4 | 0.45 | ena.study_description | randomised controlled trial conducted in rural Burkina Faso |
| SAMN41447806 | subject_id | 101 | R1 | 0.70 | sample.name_rule:library_names | incl_se1g_101 |
Sequencing
736 runs over 736 samples · mean 17.37 Gbp per run (median 20.14 Gbp, total 12,784.15 Gbp; 736 runs with a base count) · layout SINGLE 736 · platform ILLUMINA 736 · models Illumina NovaSeq 6000 (736) · 92% of runs with a Sandpiper profile · first public 2024-05-24
Authors (20)
Deng L first · Taelman S · Olm MR · Toe LC · Balini E · Ouédraogo LO · Bastos-Moreira Y · Argaw A · Tesfamariam K · Sonnenburg ED · Hanley-Cook GT · Ouédraogo M · Ganaba R · Van Criekinge W · Huybregts L · Stock M · Kolsteren P · Sonnenburg JL · Lachat C · Dailey-Chwalibóg T last
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA1113165.csv.gz (20.7 KB) · parquet (100.3 KB) — all 736 samples, every field with route and confidence · PRJNA1113165_determinations.csv.gz (19.1 KB) — 2,944 evidence rows