Fecal metagenomes of IBS-D patients on S. boulardii, Wuhan
103 fecal samples from IBS-D patients in Wuhan, China, studying the effect of the probiotic Saccharomyces boulardii on gut microbiota in an intervention design. machine-written summary
103 samples · 103 runs · CN · Age unknown · 2024 · 13.36 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 824 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| – Abstract / description | no abstract or project description |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Probiotic (live microorganisms; single strain or mixture) design single_arm_before_after · population ibs · Saccharomyces boulardii probiotic treatment in IBS-D patients
“IBS-D patients receiving S. boulardii treatment” — bioproject.description (study level; per-sample arms are in the intervention column below)
Genera, mean relative abundance over 92 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 103 | 100% | 103 | |||
| health_condition | 103 | 100% | 103 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 103 | 100% | 103 | |||
| detailed_location | 103 | 100% | ||||
| health_condition_detail | 103 | 100% | 103 | |||
| latitude | 103 | 100% | 103 | |||
| location_locality | 103 | 100% | 103 | |||
| location_region | 103 | 100% | 103 | |||
| longitude | 103 | 100% | 103 |
Archive description
A growing body of evidence implicates the gut microbiome as a critical factor in irritable bowel syndrome (IBS) pathophysiology, prompting the exploration of probiotics, such as Saccharomyces boulardii (S. boulardii), for IBS treatment. However, the effects of S. boulardii on the gut microbiota of IBS patients are still not fully understood. Therefore, fecal metagenomes were analyzed for IBS-D patients receiving S. boulardii treatment.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.78. Assay shotgun_dna.
- host study.title · “irritable bowel syndrome patients”
- body site study.title · “fecal metagenomes”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN41770116 | collection_date | 2020 | R1 | 0.90 | biosample.attribute:collection_date | 2020 |
| SAMN41770116 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Wuhan |
| SAMN41770116 | health_condition | ibs | R1 | 0.85 | biosample.attribute:title | Metagenome or environmental sample from human gut metagenome |
| SAMN41770116 | health_condition_detail | Metagenome or environmental sample from human gut metagenome | R1 | 0.85 | biosample.attribute:title | Metagenome or environmental sample from human gut metagenome |
| SAMN41770116 | latitude | 30.1100 | R1 | 0.90 | biosample.attribute:lat_lon | 30.11 N 114.23 E |
| SAMN41770116 | location_locality | Wuhan | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Wuhan |
| SAMN41770116 | location_region | Hubei | R1 | 0.60 | biosample.attribute:lat_lon | 30.11 N 114.23 E |
| SAMN41770116 | longitude | 114.2300 | R1 | 0.90 | biosample.attribute:lat_lon | 30.11 N 114.23 E |
Sequencing
103 runs over 103 samples · mean 13.46 Gbp per run (median 13.36 Gbp, total 1,386.65 Gbp; 103 runs with a base count) · layout PAIRED 103 · platform ILLUMINA 103 · models Illumina NovaSeq 6000 (103) · 89% of runs with a Sandpiper profile · first public 2024-12-29
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, subject_id. Share metadata
Downloads
PRJNA1121964.csv.gz (3.3 KB) · parquet (74.0 KB) — all 103 samples, every field with route and confidence · PRJNA1121964_determinations.csv.gz (5.4 KB) — 824 evidence rows