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PRJNA1122782 SRP513288

Gut microbiota in pediatric Crohn's disease with IDA, NYC

Evidence for altered gut microbiota in pediatric quiescent Crohn's disease patients with iron deficiency anemia

40 stool samples from pediatric Crohn's disease patients in New York, NY, studied for links between gut microbiota and iron deficiency anemia in quiescent disease, using a cross-sectional design. machine-written summary

40 samples · 40 runs · US · Child · 2025 · 3.55 Gbp / sample

Sources
✓Sequence archive 340✓Abstract / description 20–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive340 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude)
✓ Abstract / description20 sample values (health condition, health condition detail)
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 sampling locations · 1 country
Age
child40
Condition
crohns_disease40
Country
US40
Body site
primary40
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 40 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)all projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 3.55 Gbp per sample0130Gbp
Community composition
Phocaeicola 14.1%Bacteroides 13.1%Mediterraneibacter 8.9%Faecalibacterium 5.3%Escherichia 3.6%Blautia_A 3.5%Bifidobacterium 3.2%Prevotella 2.9%Roseburia 2.5%Alistipes 1.9%Collinsella 1.5%Enterocloster 1.4%not assigned to a genus 6.3%other genera 31.7%

Genera, mean relative abundance over 40 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category40 100%
country40 100%40
health_condition40 100%3010
subject_id40 100%40
collection_date40 100%40
detailed_location40 100%
health_condition_detail40 100%3010
latitude40 100%40
location_locality40 100%40
location_region40 100%40
longitude40 100%40
Papers (1)
  • Altered Gut Microbiota in Pediatric Quiescent Crohn's Disease Patients with Iron Deficiency Anemia. 2026 PMID 41423811 own_data
Details
Archive description

The study investigates the etiology of Iron Deficiency Anemia (IDA) in pediatric patients with quiescent Crohn's disease, hypothesizing that differences in microbiota and immunologic response may be associated with IDA. Utilizing cross-sectional, descriptive, and analytical study designs, stool samples from 143 patients stored in the Jill Roberts Institute Live Cell Bank were evaluated through 16S microbiome analysis and Shotgun Metagenomics.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of child by deterministic_prior with confidence 0.90. Assay shotgun_dna.

  • host external_curation.infant_catalog · “infant triage reason_code age_child_over_36m”
  • body site study.title · “Evidence for altered gut microbiota in pediatric”
  • body site study.description · “analytical study designs, stool samples from 143”
  • life stage external_curation.infant_catalog · “infant triage reason_code age_child_over_36m”
  • life stage study.title · “gut microbiota in pediatric quiescent Crohn's disease”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN41789876collection_date2022R10.90biosample.attribute:collection_date2022
SAMN41789876countryUSR10.90sample.attr.geo_loc_nameUSA: New York, NY
SAMN41789876health_conditioncrohns_diseaseR10.85biosample.attribute:descriptionIDA with CD
SAMN41789944health_conditioncrohns_diseaseR40.50study.titlepediatric quiescent Crohn's disease patients
SAMN41789876health_condition_detailIDA with CDR10.85biosample.attribute:descriptionIDA with CD
SAMN41789944health_condition_detailquiescent Crohn's disease patients with iron deficiency anemiaR40.50study.titlepediatric quiescent Crohn's disease patients
SAMN41789876latitude40.7100R10.90biosample.attribute:lat_lon40.71 N 74.0 W
SAMN41789876location_localityNew YorkR10.85biosample.attribute:geo_loc_nameUSA: New York, NY
SAMN41789876location_regionNew YorkR10.85biosample.attribute:geo_loc_nameUSA: New York, NY
SAMN41789876longitude-74.0000R10.90biosample.attribute:lat_lon40.71 N 74.0 W
SAMN41789876subject_idRIP0290R10.85sample.attr.subjectRIP0290
Sequencing

40 runs over 40 samples · mean 3.67 Gbp per run (median 3.55 Gbp, total 146.77 Gbp; 40 runs with a base count) · layout PAIRED 40 · platform ILLUMINA 40 · models Illumina HiSeq X (40) · 100% of runs with a Sandpiper profile · first public 2025-07-03 – 2025-07-27

Authors (0)

No author record.

Downloads

PRJNA1122782.csv.gz (2.0 KB) · parquet (71.8 KB) — all 40 samples, every field with route and confidence · PRJNA1122782_determinations.csv.gz (3.2 KB) — 360 evidence rows

Samples (40 · every field this project has values for · hover a cell for its source)
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