Infant gut microbiome, maternal obesity, UAE, longitudinal cohort
203 stool samples from infants in the United Arab Emirates, followed over the first year of life, studying whether maternal pre-pregnancy obesity relates to infant gut microbiome composition; longitudinal cohort design. machine-written summary
203 samples · 203 runs · AE · Infant / toddler · 2024 · 2.31 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 609 sample values (country, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 1,085 sample values (collection date, feeding mode, location locality, location site, maternal antibiotics, preterm status) · PMC11287775 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
46 of 46 people sampled more than once (203 samples; median 4, up to 5 per person). Schedule stated by the source: “stool samples collected throughout the first year of life (multiple timepoints per infant)” (time origin: birth); stated follow-up 12 mo.
Genera, mean relative abundance over 179 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 203 | 100% | ||||
| country | 203 | 100% | 203 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 203 | 100% | 203 | |||
| collection_date | 203 | 100% | 203 | |||
| detailed_location | 203 | 100% | ||||
| location_locality | 203 | 100% | 203 | |||
| location_site | 203 | 100% | 203 | |||
| maternal_antibiotics | 203 | 100% | 203 | |||
| preterm_status | 203 | 100% | 203 | |||
| timepoint_label | 203 | 100% | 203 | |||
| feeding_mode | 70 | 34% | 70 |
- The infants' gut microbiome: setting the stage for the early onset of obesity. PMID 39081889 PMC11287775 curated
Archive description
In the past three decades, dietary and lifestyle changes worldwide have resulted in a global increase in the prevalence of obesity in both adults and children. Known to be highly influenced by genetic, environmental and lifestyle factors, obesity is characterized by a low grade chronic inflammation that contributes to the development of other metabolic diseases such as diabetes and cardiovascular disease. Recently, the gut microbiome has been added as a cause to the development of obesity. As differences in the microbiome between obese and normoweight individuals have been observed, we set out to determine whether infants harbor an obesogenic microbiome early on and whether the pre-pregnancy status of the mother is correlated to their infants microbiome composition. Using shotgun sequencing, we analyzed stool samples throughout the first year of life from infants born to obese and normoweight mothers. We found that the infants microbiome diversity at taxonomic and functional levels was significantly influenced by time but not by the mothers pre pregnancy status. Overall, no deterministic succession of taxa or functions was observed.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and child and adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.title · “Infant gut microbiome study”
- body site study.description · “disease. Recently, the gut microbiome has been”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.title · “Infant gut microbiome study”
- life stage study.description · “both adults and children . Known to”
- life stage study.description · “obesity in both adults and children. Known”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN42183894 | collection_date | 2017-08/2019-05 | R3 | 0.70 | paper.fulltext.methods | 19-month period between August 2017 and May 2019 |
| SAMN42183894 | country | AE | R1 | 0.90 | biosample_attr | United Arab Emirates |
| SAMN42183894 | feeding_mode | exclusive_breast | R3 | 0.40 | paper.fulltext.results | all infants were exclusively breastfed up to their first 2 months |
| SAMN42183894 | location_locality | Dubai | R3 | 0.70 | paper.fulltext.methods | Participants were recruited at Latifa Hospital in Dubai |
| SAMN42183894 | location_site | Latifa Hospital | R3 | 0.70 | paper.fulltext.methods | Participants were recruited at Latifa Hospital in Dubai |
| SAMN42183894 | maternal_antibiotics | no | R3 | 0.40 | paper.fulltext.methods | should not have taken any course of antibiotics from 28 weeks |
| SAMN42183894 | preterm_status | term | R3 | 0.80 | paper.fulltext.results | All infants included in the study were born at term |
| SAMN42183894 | subject_id | IGM10 | R1 | 0.70 | sample.name_rule:library_names | IGM10-tpB |
| SAMN42183894 | timepoint_label | tpB | R1 | 0.80 | biosample_attr | tpB |
Sequencing
203 runs over 203 samples · mean 2.25 Gbp per run (median 2.31 Gbp, total 456.80 Gbp; 203 runs with a base count) · layout PAIRED 203 · platform ILLUMINA 203 · models Illumina NovaSeq 6000 (203) · 88% of runs with a Sandpiper profile · first public 2024-07-05 – 2024-07-29
Authors (10)
Vallès Y first · Arshad M · Abdalbaqi M · Inman CK · Ahmad A · Drou N · Gunsalus KC · Ali R · Tahlak M · Abdulle A last
Downloads
PRJNA1130109.csv.gz (6.5 KB) · parquet (78.3 KB) — all 203 samples, every field with route and confidence · PRJNA1130109_determinations.csv.gz (9.1 KB) — 1,694 evidence rows