Gut virome-bacteriome in first-episode schizophrenia, China
Case-control study of 95 fecal samples from first-episode schizophrenia patients and healthy controls in China, analyzing gut virome, bacteriome, and peripheral metabolome composition and their interrelationships. machine-written summary
95 samples · 95 runs · CN · Adult · 2024 · 6.12 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 665 sample values (collection date, country, health condition, health condition detail, latitude, location region, longitude) |
| ✓ Abstract / description | 95 sample values (subject id) |
| ✓ Full text | 95 sample values (location site) · PMC11779829 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| ✓ External resources | 95 sample values (antibiotic exposure) · from BugSigDB |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 85 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 95 | 100% | ||||
| country | 95 | 100% | 95 | |||
| health_condition | 95 | 100% | 95 | |||
| subject_id | 95 | 100% | 95 | |||
| antibiotic_exposure | 95 | 100% | 95 | |||
| collection_date | 95 | 100% | 95 | |||
| detailed_location | 95 | 100% | ||||
| health_condition_detail | 95 | 100% | 95 | |||
| latitude | 95 | 100% | 95 | |||
| location_region | 95 | 100% | 95 | |||
| location_site | 95 | 100% | 95 | |||
| longitude | 95 | 100% | 95 |
- Alterations in fecal bacteriome virome interplay and microbiota-derived dysfunction in patients with schizophrenia. 2025 PMID 39880843 PMC11779829 own_data
Archive description
This project encompasses the collection and analysis of fecal microbiome data from 48 first-episode schizophrenia patients and 47 healthy controls.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.description · “and analysis of fecal microbiome data from”
- body site external_curation.infant_catalog · “body_site_call gut”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN42489773 | antibiotic_exposure | no | R2 | 0.60 | external.bugsigdb source | Antibiotics exclusion: 1 month |
| SAMN42489773 | collection_date | 2022 | R1 | 0.90 | biosample.attribute:collection_date | 2022 |
| SAMN42489773 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMN42489773 | health_condition | neurological_psychiatric | R1 | 0.90 | biosample_attr | schizophrenia |
| SAMN42489773 | health_condition_detail | schizophrenia | R1 | 0.90 | sample.attr.host_disease | schizophrenia |
| SAMN42489773 | latitude | 30.6700 | R1 | 0.90 | biosample.attribute:lat_lon | 30.67 N 104.06 E |
| SAMN42489773 | location_region | Sichuan | R1 | 0.60 | biosample.attribute:lat_lon | 30.67 N 104.06 E |
| SAMN42489773 | location_site | West China Hospital of Sichuan University | R3 | 0.70 | paper.fulltext.methods | recruited participants from West China Hospital of Sichuan University |
| SAMN42489773 | longitude | 104.0600 | R1 | 0.90 | biosample.attribute:lat_lon | 30.67 N 104.06 E |
| SAMN42489773 | subject_id | SAMN42489773 | R4 | 0.60 | design.one_sample_per_subject:description | fecal microbiome data from 48 first-episode schizophrenia patients and 47 healthy controls |
Sequencing
95 runs over 95 samples · mean 6.56 Gbp per run (median 6.12 Gbp, total 623.09 Gbp; 95 runs with a base count) · layout PAIRED 95 · platform ILLUMINA 95 · models Illumina NovaSeq 6000 (95) · 89% of runs with a Sandpiper profile · first public 2024-07-23
Authors (21)
Tao S first · Wu Y · Xiao L · Huang Y · Wang H · Tang Y · Liu S · Liu Y · Ma Q · Yin Y · Dai M · Xie M · Cai J · Zhao Z · Lv Q · Zhang J · Zhang M · Wei M · Chen Y · Li M · Wang Q last
Downloads
PRJNA1135717.csv.gz (3.5 KB) · parquet (75.1 KB) — all 95 samples, every field with route and confidence · PRJNA1135717_determinations.csv.gz (6.3 KB) — 950 evidence rows