JCM-16021 herbal therapy trial in IBS-D gut microbiota, Hong Kong
723 gut microbiome samples from Hong Kong, collected in a multi-center, double-blinded, randomized placebo-controlled trial testing JCM-16021, a Chinese herbal formula, in diarrhea-predominant irritable bowel syndrome (IBS-D). machine-written summary
723 samples · 723 runs · HK · Age unknown · 2024 · 7.72 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,446 sample values (collection date, country) |
| ✓ Abstract / description | 1,446 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin design randomized_controlled_trial · population ibs · JCM-16021 Chinese herbal formula vs placebo for IBS-D
“double-blinded randomized placebo-controlled trial” — study.title (study level; per-sample arms are in the intervention column below)
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 723 | 100% | 723 | |||
| health_condition | 723 | 100% | 723 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 723 | 100% | 723 | |||
| health_condition_detail | 723 | 100% | 723 |
- Butyrate-producing commensal bacteria mediates the efficacy of herbal medicine JCM-16021 on abdominal pain in diarrhea-predominant irritable bowel syndrome: a randomized clinical trial. 2025 PMID 40639240 own_data
Archive description
In this study, we performed a multi-center, double-blinded randomized placebo-controlled trial to investigate the efficacy and safety of JCM-16021, a Chinese herbal formula, in treating diarrhea-predominant irritable bowel syndrome (IBS-D). We also explored the impact of JCM-16021 on gut microbiota, a potential underlying mechanism of action.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.70. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host run.scientific_name · “gut metagenome”
- body site run.scientific_name · “gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN42767269 | collection_date | 2020-12-04 | R1 | 0.90 | biosample.attribute:collection_date | 2020-12-04 |
| SAMN42767269 | country | HK | R1 | 0.90 | sample.attr.geo_loc_name | Hong Kong |
| SAMN42767269 | health_condition | ibs | R4 | 0.50 | paper.abstract | Irritable bowel syndrome with diarrhea (IBS-D) presents significant treatment challenges |
| SAMN42767269 | health_condition_detail | IBS-D (diarrhea-predominant irritable bowel syndrome) | R4 | 0.50 | paper.abstract | Irritable bowel syndrome with diarrhea (IBS-D) presents significant treatment challenges |
Sequencing
723 runs over 723 samples · mean 8.31 Gbp per run (median 7.72 Gbp, total 6,005.51 Gbp; 723 runs with a base count) · layout PAIRED 723 · platform DNBSEQ 723 · models DNBSEQ-T7 (723) · 0% of runs with a Sandpiper profile · first public 2024-07-29
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, subject_id. Share metadata
Downloads
PRJNA1139229.csv.gz (18.2 KB) · parquet (98.2 KB) — all 723 samples, every field with route and confidence · PRJNA1139229_determinations.csv.gz (19.3 KB) — 2,892 evidence rows