Gut microbiome in HCC patients on anti-PD-1 therapy, China
45 stool samples from adult hepatocellular carcinoma patients in China, comparing gut microbiota between responders and non-responders to anti-PD-1-based combination therapy (case-control design). machine-written summary
45 samples · 45 runs · CN · Age unknown · 2024 · 6.26 Gbp / sample · cohort Two stable gut microbiome guilds predict liver tum
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 90 sample values (collection date, country) |
| ✓ Abstract / description | 45 sample values (location site) |
| ✓ Full text | 90 sample values (health condition, health condition detail) · PMC11484251, PMC13147943 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 41 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 45 | 100% | ||||
| country | 45 | 100% | 45 | |||
| health_condition | 45 | 100% | 45 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 45 | 100% | 45 | |||
| detailed_location | 45 | 100% | ||||
| health_condition_detail | 45 | 100% | 45 | |||
| location_site | 45 | 100% | 45 |
- Gut microbiota as a prognostic biomarker for unresectable hepatocellular carcinoma treated with anti-PD-1 therapy. 2024 PMID 39421302 PMC11484251 own_data
- Two stable gut microbiome guilds predict liver tumor class and treatment responses. 2026 PMID 42099457 PMC13147943 unsure
Archive description
A dataset of 45 samples with HCC
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.65. Assay shotgun_dna.
- host run.library_source · “METAGENOMIC”
- body site study.title · “Gut microbiota”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN42934614 | collection_date | 2021-01-01 | R1 | 0.90 | biosample.attribute:collection_date | 2021-01-01 |
| SAMN42934614 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMN42934614 | health_condition | other_cancer | R3 | 0.70 | paper.fulltext.abstract | unresectable HCC |
| SAMN42934614 | health_condition_detail | Unresectable hepatocellular carcinoma treated with anti-PD-1-based combination therapy | R3 | 0.70 | paper.fulltext.abstract | unresectable hepatocellular carcinoma (HCC) |
| SAMN42934614 | location_site | Cancer Hospital of the Chinese Academy of Medical Sciences | R4 | 0.50 | paper.abstract | Cancer Hospital of the Chinese Academy of Medical Sciences |
Sequencing
45 runs over 45 samples · mean 6.20 Gbp per run (median 6.26 Gbp, total 279.03 Gbp; 45 runs with a base count) · layout PAIRED 42, SINGLE 3 · platform ILLUMINA 45 · models Illumina NovaSeq X (45) · 91% of runs with a Sandpiper profile · first public 2024-08-12
Authors (24)
Xin Y first · Peng G · Song W · Zhou X · Huang X · Cao X last · Liu Y first · Zhang Z · Wu G · Li B · Wang L · Wang J · Wei Z · Wang Z · Yang J · Zhang K · Zhang T · Tao X · Chen T · Fan J · Zhou J · Yang X · Zhao L · Wei Y last
Downloads
PRJNA1142390.csv.gz (2.1 KB) · parquet (71.5 KB) — all 45 samples, every field with route and confidence · PRJNA1142390_determinations.csv.gz (1.7 KB) — 225 evidence rows