Gut metagenomes in CRC patients vs controls, China (case-control)
81 fecal metagenome samples from China, comparing colorectal cancer patients and healthy controls in a case-control design, studying links between gut microbiota tryptophan metabolism (indole-3-lactic acid) and CRC progression. machine-written summary
81 samples · 81 runs · CN · Age unknown · 2025 · 10.85 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 324 sample values (collection date, country, latitude, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 162 sample values (antibiotic exposure, location site) · PMC12118437 |
| ✓ Supplementary tables | 102 sample values (age, sex) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 81 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 51 | 63% | ||||
| country | 81 | 100% | 81 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| antibiotic_exposure | 81 | 100% | 81 | |||
| collection_date | 81 | 100% | 81 | |||
| detailed_location | 81 | 100% | ||||
| latitude | 81 | 100% | 81 | |||
| location_site | 81 | 100% | 81 | |||
| longitude | 81 | 100% | 81 | |||
| age_at_collection_days | 51 | 63% | 51 | |||
| sex | 51 | 63% | 51 |
- Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming. 2025 PMID 40409349 PMC12118437 own_data
Archive description
The sequencing samples are feces from colorectal cancer patients and healthy controls, and the sequencing method is metagenomic sequencing.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.75. Assay shotgun_dna.
- host study.description · “colorectal cancer patients and healthy controls”
- body site study.description · “The sequencing samples are feces”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN43516960 | age_at_collection_days | 15340 | R2 | 0.85 | paper.supp.TableS1 Clinical information of patients with CRC.xlsx[Sheet1!age] | 42 |
| SAMN43516960 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | not undergone antibiotic treatment for a minimum of 1 month |
| SAMN43516960 | collection_date | 2022-10-15 | R1 | 0.90 | biosample.attribute:collection_date | 2022-10-15 |
| SAMN43516960 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMN43516960 | latitude | 32.0000 | R1 | 0.90 | biosample.attribute:lat_lon | 32 N 119 E |
| SAMN43516960 | location_site | Nanjing Drum Tower Hospital | R3 | 0.70 | paper.fulltext.methods | fecal samples were obtained from Nanjing Drum Tower Hospital |
| SAMN43516960 | longitude | 119.0000 | R1 | 0.90 | biosample.attribute:lat_lon | 32 N 119 E |
| SAMN43516960 | sex | male | R2 | 0.85 | paper.supp.TableS1 Clinical information of patients with CRC.xlsx[Sheet1!gender] | male |
Sequencing
81 runs over 81 samples · mean 10.95 Gbp per run (median 10.85 Gbp, total 887.14 Gbp; 81 runs with a base count) · layout SINGLE 81 · platform ILLUMINA 81 · models Illumina NovaSeq 6000 (81) · 100% of runs with a Sandpiper profile · first public 2025-10-23
Authors (12)
Zhou S first · Wang K · Huang J · Xu Z · Yuan Q · Liu L · Wang Z · Miao J · Wang H · Wang T · Guan W · Ding C last
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJNA1157583.csv.gz (3.2 KB) · parquet (74.1 KB) — all 81 samples, every field with route and confidence · PRJNA1157583_determinations.csv.gz (4.6 KB) — 588 evidence rows