Gut Microbiome in US Nurses: Mind-Body Study (NHSII Sub-Study)
Cross-sectional study of 818 stool samples from nurses enrolled in the Nurses' Health Study II (Mind-Body sub-study), examining gut microbiome associations with psychosocial factors and imidazole propionate-related metabolism. machine-written summary
818 samples · 818 runs · Adult · 2025 · 3.49 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 2,454 sample values (health condition detail, sex, subject id) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC13548641 |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
213 of 213 people sampled more than once (818 samples; median 4, up to 4 per person). Schedule stated by the source: “Participants provided one or two stool samples between 2013 and 2014; exact intervals between stool samples not stated”.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 818 | 100% | ||||
| country | 0 | 0% | ||||
| health_condition | 0 | 0% | ||||
| subject_id | 818 | 100% | 818 | |||
| health_condition_detail | 818 | 100% | 818 | |||
| sex | 818 | 100% | 818 |
- Circulating imidazole propionate and coronary heart disease risk: interplay between histidine intake, fiber, and gut microbiome. 2026 PMID 42332773 PMC13548641 unsure
Archive description
The Mind-Body Study is a sub-study of the Nurses' Health Study II (NHSII) which investigated associations between biomarkers and psychosocial factors. The prevalences of clinically meaningful depressive symptoms, mild-to-severe anxiety symptoms, experiencing major-life discrimination, and food addiction were 19%, 21%, 30%, and 5% respectively. These participants were more likely to have experienced childhood abuse and take psychotropic medications but less likely to have chronic conditions such as diabetes and hypertension than participants in the larger NHSII cohort. Participants (n = 213, mean age = 60.6) provided one or two separate stool samples for microbiome profiling between 2013 and 2014, and completed two online psychosocial assessments 10 months apart. The participants also... (for more see dbGaP study page.)
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.72. Assay shotgun_dna.
- host run.scientific_name · “Homo sapiens”
- body site study.description · “provided one or two separate stool samples”
- life stage study.description · “mean age = 60.6”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN45077890 | health_condition_detail | is tumor: no | R1 | 0.85 | sample.attr.is_tumor | No |
| SAMN45077890 | sex | female | R1 | 0.90 | sample.attr.sex | female |
| SAMN45077890 | subject_id | 5301608 | R1 | 0.85 | sample.attr.gap_subject_id | 5301608 |
Sequencing
818 runs over 818 samples · mean 3.63 Gbp per run (median 3.49 Gbp, total 2,972.88 Gbp; 818 runs with a base count) · layout SINGLE 817, PAIRED 1 · platform ILLUMINA 818 · models Illumina HiSeq 2000 (818) · 0% of runs with a Sandpiper profile · first public 2025-04-17
Authors (15)
Liang X first · Zhu L · Li J · Li Y · Ivey KL · Lee KH · Eliassen AH · Chan AT · Huttenhower C · Zhang C · Hu FB · Qi Q · Hu Y · Rimm EB · Sun Q last
Help complete this project
2 of the 4 core fields are below 50% coverage: country, health_condition. Share metadata
Downloads
PRJNA1164832.csv.gz (19.3 KB) · parquet (96.6 KB) — all 818 samples, every field with route and confidence · PRJNA1164832_determinations.csv.gz (13.4 KB) — 2,454 evidence rows