Gut metagenomes in HIV patients with/without NAFLD, Guangzhou
12 fecal metagenome samples from adults living with HIV in Guangzhou, China, comparing those with and without NAFLD to study links between gut microbiota and metabolic disorders; case-control design. machine-written summary
12 samples · 12 runs · CN · Adult · 2024 · 10.02 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 72 sample values (collection date, country, health condition, health condition detail, location locality, subject id) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC11892071 |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 11 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 12 | 100% | ||||
| country | 12 | 100% | 12 | |||
| health_condition | 12 | 100% | 12 | |||
| subject_id | 12 | 100% | 12 | |||
| collection_date | 12 | 100% | 12 | |||
| detailed_location | 12 | 100% | ||||
| health_condition_detail | 12 | 100% | 12 | |||
| location_locality | 12 | 100% | 12 |
- Decreased intestinal abundance of <i>Akkermansia muciniphila</i> is associated with metabolic disorders among people living with HIV. 2025 PMID 40052450 PMC11892071 unsure
Archive description
This project involves metagenomic sequencing of fecal samples from 12 individuals, including 6 patients with NAFLD and 6 without NAFLD. The primary goal of the study is to explore the relationship between gut microbiota and metabolic disorders (overweight/obesity, NAFLD, hyperlipidemia) in people living with HIV (PLWH).
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “sequencing of human fecal samples from NAFLD”
- body site study.description · “metagenomic sequencing of fecal samples from 12”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN44018452 | collection_date | 2022-02-15 | R1 | 0.90 | biosample.attribute:collection_date | 2022-02-15 |
| SAMN44018452 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Guangzhou |
| SAMN44018452 | health_condition | liver_disease | R1 | 0.85 | biosample.attribute:description | HIV_NAFLD |
| SAMN44018452 | health_condition_detail | HIV_NAFLD | R1 | 0.85 | biosample.attribute:description | HIV_NAFLD |
| SAMN44018452 | location_locality | Guangzhou | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Guangzhou |
| SAMN44018452 | subject_id | H21 | R1 | 0.85 | biosample.attribute:alias | H21 |
Sequencing
12 runs over 12 samples · mean 10.01 Gbp per run (median 10.02 Gbp, total 120.14 Gbp; 12 runs with a base count) · layout PAIRED 12 · platform ILLUMINA 12 · models Illumina HiSeq 2000 (12) · 92% of runs with a Sandpiper profile · first public 2024-10-13
Authors (12)
Qian Z first · Chen S · Liao X · Xie J · Xu Y · Zhong H · Ou L · Zuo X · Xu X · Peng J · Wu J · Cai S last
Downloads
PRJNA1167913.csv.gz (1.2 KB) · parquet (69.9 KB) — all 12 samples, every field with route and confidence · PRJNA1167913_determinations.csv.gz (1.1 KB) — 72 evidence rows