Gut metagenome in IBD vs healthy controls, Barcelona, Spain
Case-control study of 212 fecal shotgun metagenome samples from Barcelona, Spain, comparing Crohn's disease and ulcerative colitis patients with healthy controls to identify microbiome markers and mechanisms of disease. machine-written summary
212 samples · 212 runs · ES · Age unknown · 2025 · 3.74 Gbp / sample · cohort Microbial, functional, and virulence biomarkers as
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,852 sample values (collection date, country, health condition, health condition detail, latitude, location locality, longitude, subject id) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC12172205, PMC13352609 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
61 of 117 people sampled more than once (156 samples; median 2, up to 6 per person). Schedule stated by the source: “Baseline then followed until relapse or for max 12 months; no fixed intervals stated” (time origin: enrolment); stated follow-up 12 mo.
Genera, mean relative abundance over 169 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 212 | 100% | 212 | |||
| health_condition | 184 | 87% | 184 | |||
| subject_id | 212 | 100% | 212 | |||
| collection_date | 212 | 100% | 212 | |||
| detailed_location | 212 | 100% | ||||
| latitude | 212 | 100% | 212 | |||
| location_locality | 212 | 100% | 212 | |||
| longitude | 212 | 100% | 212 | |||
| timepoint_label | 212 | 100% | 212 | |||
| health_condition_detail | 184 | 87% | 184 |
- Microbiome multi-omics analysis reveals novel biomarkers and mechanisms linked with CD etiopathology. 2025 PMID 40524271 PMC12172205 own_data
- Microbial, functional, and virulence biomarkers associated with familial risk of Crohn's disease and ulcerative colitis. 2026 PMID 42277905 PMC13352609 unsure
Archive description
Human gut metagenome of IBD patients and healthy controls
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.78. Assay shotgun_dna.
- host run.scientific_name · “human gut metagenome”
- body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN44485019 | collection_date | 2010 | R1 | 0.90 | biosample.attribute:collection_date | 2010 |
| SAMN44485019 | country | ES | R1 | 0.90 | sample.attr.geo_loc_name | Spain: Barcelona |
| SAMN44485019 | health_condition | crohns_disease | R1 | 0.70 | sample.name_rule:alias | V1.CD10-0 |
| SAMN44485019 | health_condition_detail | CD | R1 | 0.70 | sample.name_rule:alias | V1.CD10-0 |
| SAMN44485019 | latitude | 41.4280 | R1 | 0.90 | biosample.attribute:lat_lon | 41.427991 N 2.141921 E |
| SAMN44485019 | location_locality | Barcelona | R1 | 0.85 | biosample.attribute:geo_loc_name | Spain: Barcelona |
| SAMN44485019 | longitude | 2.1419 | R1 | 0.90 | biosample.attribute:lat_lon | 41.427991 N 2.141921 E |
| SAMN44485019 | subject_id | CD10 | R1 | 0.70 | sample.name_rule:alias | V1.CD10-0 |
| SAMN44485019 | timepoint_label | 0 | R1 | 0.70 | sample.name_rule:alias | V1.CD10-0 |
Sequencing
212 runs over 212 samples · mean 4.25 Gbp per run (median 3.74 Gbp, total 900.49 Gbp; 212 runs with a base count) · layout PAIRED 212 · platform ILLUMINA 212 · models Illumina HiSeq X (212) · 80% of runs with a Sandpiper profile · first public 2025-09-21
Authors (17)
Serrano-Gómez G first · Yañez F · Soler Z · Pons-Tarin M · Mayorga L · Herrera-deGuise C · Borruel N · Rodriguez-Sinovas A · Consegal M · Manjón I · Vega-Abellaneda S · Manichanh C last · Zaida S · Pons-Tarín M · Maria TC · Natalia B · Francisco G
Downloads
PRJNA1171764.csv.gz (6.1 KB) · parquet (78.2 KB) — all 212 samples, every field with route and confidence · PRJNA1171764_determinations.csv.gz (13.1 KB) — 1,852 evidence rows