2'-FL effect on gut microbiota across age groups, Belgium
126 samples from Belgium (84 unknown age, 42 infant) representing six age groups from infancy to 70-year-old adults, testing response of gut microbiota to 2'-FL using ex vivo SIFR technology. machine-written summary
126 samples · 126 runs · BE · Infant / toddler · 2024 · 0.84 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 399 sample values (age, country, diet, intervention, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC11723031 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 114 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 42 | 33% | ||||
| country | 126 | 100% | 126 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| timepoint_label | 126 | 100% | 126 | |||
| intervention | 84 | 67% | 84 | |||
| age_at_collection_days | 42 | 33% | 42 | |||
| diet | 21 | 17% | 21 |
- The Bifidogenic Effect of 2'Fucosyllactose Is Driven by Age-Specific Bifidobacterium Species, Demonstrating Age as an Important Factor for Gut Microbiome Targeted Precision Medicine. PMID 39796584 PMC11723031 curated
Archive description
In this project we evaluated the response of human gut microbiota from six age groups, spanning from infancy to 70-year-old adults to 2FL using the ex vivo SIFR technology
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.description · “response of human gut microbiota from six”
- body site external_curation.infant_catalog · “infant triage verdict include (gut/stool scope)”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “groups, spanning from infancy to 70-year-old adults”
- life stage study.description · “infancy to 70-year-old adults to 2FL using”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN44452616 | age_at_collection_days | 183 | R1 | 0.90 | biosample_attr | BF infant |
| SAMN44452580 | country | BE | R1 | 0.90 | biosample_attr | Belgium |
| SAMN44452616 | diet | exclusive_breast_milk | R1 | 0.85 | biosample.attribute:host_age | BF infant |
| SAMN44452580 | intervention | no_intervention | R1 | 0.85 | biosample.attribute:chem_administration | NSC |
| SAMN44452580 | timepoint_label | 24h | R1 | 0.85 | biosample.attribute:perturbation | 24h |
Sequencing
126 runs over 126 samples · mean 1.01 Gbp per run (median 0.84 Gbp, total 126.99 Gbp; 126 runs with a base count) · layout PAIRED 126 · platform ILLUMINA 126 · models Illumina HiSeq X (126) · 90% of runs with a Sandpiper profile · first public 2024-12-01
Authors (9)
Firrman J first · Deyaert S · Mahalak KK · Liu L · Baudot A · Joossens M · Poppe J · Cameron SJS · Van den Abbeele P last
Help complete this project
3 of the 4 core fields are below 50% coverage: age_category, health_condition, subject_id. Share metadata
Downloads
PRJNA1177813.csv.gz (4.1 KB) · parquet (75.1 KB) — all 126 samples, every field with route and confidence · PRJNA1177813_determinations.csv.gz (2.6 KB) — 399 evidence rows