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PRJNA1195696 SRP550719

Gut microbiome in ALD vs healthy controls, case-control

Homo sapiens Raw sequence reads

75 gut metagenome samples compared bacterial communities in ALD (alcohol-related liver disease) versus healthy controls, using a case-control design; location, ages, and participant numbers not reported. machine-written summary

75 samples · 75 runs · Age unknown · 2025 · 12.17 Gbp / sample

Sources
○Sequence archive✓Abstract / description 75–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
○ Sequence archiverecords read; no usable sample values
✓ Abstract / description75 sample values (health condition detail)
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet · share metadata
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
Age
unknown75
Body site
primary75
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 2 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 73 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 12.17 Gbp per sample0130Gbp
Community composition
Blautia_A 7.3%Phocaeicola 7.2%Bacteroides 6.8%Streptococcus 5.2%Prevotella 5.0%Mediterraneibacter 4.8%Faecalibacterium 4.1%Escherichia 4.0%Roseburia 3.9%Megamonas 3.5%Klebsiella 2.5%Alistipes 2.4%not assigned to a genus 3.1%other genera 40.1%

Genera, mean relative abundance over 71 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category0 0%
country0 0%
health_condition0 0%
subject_id0 0%
health_condition_detail75 100%75
Details
Archive description

the aim of this study was to compare the bacterial communities in ALD to those of healthy controls.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.53. Assay shotgun_dna.

  • host run.scientific_name · “Homo sapiens”
  • body site sample.attr.tissue · “fecal (n=75/75)”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN45226766health_condition_detailmixed_case_control: Study compares ALD (alcoholic liver disease) cases to healthy controls; two distinct groupsR40.50study.descriptionbacterial communities in ALD to those of healthy controls
Sequencing

75 runs over 75 samples · mean 11.86 Gbp per run (median 12.17 Gbp, total 889.74 Gbp; 75 runs with a base count) · layout PAIRED 75 · platform ILLUMINA 75 · models Illumina NovaSeq 6000 (75) · 95% of runs with a Sandpiper profile · first public 2025-07-01 – 2025-07-27

Authors (0)

No author record.

Help complete this project

4 of the 4 core fields are below 50% coverage: age_category, country, health_condition, subject_id. Share metadata

Downloads

PRJNA1195696.csv.gz (2.6 KB) · parquet (71.9 KB) — all 75 samples, every field with route and confidence · PRJNA1195696_determinations.csv.gz (879 B) — 75 evidence rows

Samples (75 · every field this project has values for · hover a cell for its source)
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