Mangiferin gut metabolism in healthy and IBD adults, Belgium
48 fecal samples from adults in Belgium, including healthy controls and individuals with IBD, in an intervention study of dietary mangiferin supplementation and its microbial conversion to norathyriol. machine-written summary
48 samples · 48 runs · BE · Adult · 2025 · 13.34 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 288 sample values (collection date, country, health condition, health condition detail, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 48 sample values (antibiotic exposure) · PMC12101588 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-microbial dietary supplement (vitamins design single_arm_before_after · population healthy_control · Mangiferin oral treatment in healthy adult volunteers
“fecal samples from healthy adult volunteers treated with MAN” — abstract:40401774 (study level; per-sample arms are in the intervention column below)
longitudinal
12 of 12 people sampled more than once (48 samples; median 4, up to 5 per person) · follow-up median 1 d (max 1 d) · median interval between samples 1 d (time from timepoint labels).
Each row is one person (12 shown); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 46 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 48 | 100% | ||||
| country | 48 | 100% | 48 | |||
| health_condition | 48 | 100% | 48 | |||
| subject_id | 48 | 100% | 48 | |||
| antibiotic_exposure | 48 | 100% | 48 | |||
| collection_date | 48 | 100% | 48 | |||
| health_condition_detail | 48 | 100% | 48 | |||
| timepoint_label | 48 | 100% | 48 |
- Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism. 2025 PMID 40401774 PMC12101588 own_data
Archive description
Mangiferin (MAN) is a natural C-glycosylxanthone predominantly found in various plant species, most notably, in the leaves, stems, bark, and fruits of Mangifera indica (mango tree). Although C-glycosides are generally more metabolically stable, evidence suggests that bacterial enzymes, can deglycosylate them. Overall, our study provides new insights into the microbial metabolism of MAN. While MAN itself exhibited limited metabolic effects, its microbial conversion to the aglycone NOR, potentially mediated by specific gut bacteria such as CAKRHR01 sp934339005 and Enterococcus sp900549885, may explain some of the bioactive properties attributed to MAN.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Gut microbiota-mediated conversion of”
- body site study.description · “mediated by specific gut bacteria such as”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN46118931 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | no antibiotic use in the past 3 months |
| SAMN46118931 | collection_date | 2024 | R1 | 0.90 | biosample.attribute:collection_date | 2024 |
| SAMN46118931 | country | BE | R1 | 0.90 | sample.attr.geo_loc_name | Belgium: not further specified |
| SAMN46118931 | health_condition | ibd_unspecified | R1 | 0.85 | biosample_attr | IBD Patient |
| SAMN46118931 | health_condition_detail | IBD Patient | R1 | 0.90 | sample.attr.host_disease | IBD Patient |
| SAMN46118931 | subject_id | IBD Patient1 | R1 | 0.85 | sample.attr.host_subject_id | IBD Patient1 |
| SAMN46118931 | timepoint_label | 0h | R1 | 0.85 | sample.attr.timepoint | 0h |
Sequencing
48 runs over 48 samples · mean 13.79 Gbp per run (median 13.34 Gbp, total 662.14 Gbp; 48 runs with a base count) · layout PAIRED 48 · platform ILLUMINA 48 · models Illumina NovaSeq X Plus (48) · 96% of runs with a Sandpiper profile · first public 2025-08-26
Authors (4)
Bunt D first · Schwalbe M · Hayeeawaema F · El Aidy S last
Downloads
PRJNA1199756.csv.gz (2.1 KB) · parquet (71.2 KB) — all 48 samples, every field with route and confidence · PRJNA1199756_determinations.csv.gz (2.3 KB) — 336 evidence rows