Gut Metagenome in Chinese CAD Case-Control Study
149 gut metagenome samples from Chinese individuals (49 without coronary artery disease, 99 with CAD), studied using a case-control design to examine links between gut microbiota and coronary artery disease. machine-written summary
149 samples · 149 runs · CN · Age unknown · 2025 · 8.63 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 745 sample values (collection date, country, latitude, longitude, subject id) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 298 sample values (location locality, location site) · PMC12613830 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 148 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 149 | 100% | 149 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 149 | 100% | 149 | |||
| collection_date | 149 | 100% | 149 | |||
| detailed_location | 149 | 100% | ||||
| latitude | 149 | 100% | 149 | |||
| location_locality | 149 | 100% | 149 | |||
| location_site | 149 | 100% | 149 | |||
| longitude | 149 | 100% | 149 |
- Olsenella scatoligenes-derived skatole promotes smooth muscle cell proliferation and migration to aggravate atherosclerosis. 2025 PMID 41128819 PMC12613830 own_data
Archive description
Metagenomics shotgun sequencing data from 149 Chinese (49 with no-CAD and 99 with CAD)
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.55. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host study.description · “149 Chinese (49 with no-CAD and 99 with CAD)”
- body site sample.attr.isolation_source · “feces (n=149/149)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN46750783 | collection_date | 2019 | R1 | 0.90 | biosample.attribute:collection_date | 2019 |
| SAMN46750783 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMN46750783 | latitude | 23.1000 | R1 | 0.90 | biosample.attribute:lat_lon | 23.1 N 113.2 E |
| SAMN46750783 | location_locality | Guangzhou | R3 | 0.70 | paper.fulltext.methods | recruited at Sun Yat-sen Memorial Hospital, Sun Yat-sen University (Guangzhou, China) |
| SAMN46750783 | location_site | Sun Yat-sen Memorial Hospital, Sun Yat-sen University | R3 | 0.70 | paper.fulltext.methods | recruited at Sun Yat-sen Memorial Hospital, Sun Yat-sen University |
| SAMN46750783 | longitude | 113.2000 | R1 | 0.90 | biosample.attribute:lat_lon | 23.1 N 113.2 E |
| SAMN46750783 | subject_id | Subject_1 | R1 | 0.85 | biosample.attribute:source_material_id | Subject_1 |
Sequencing
149 runs over 149 samples · mean 8.94 Gbp per run (median 8.63 Gbp, total 1,332.61 Gbp; 149 runs with a base count) · layout PAIRED 149 · platform ILLUMINA 149 · models Illumina NovaSeq 6000 (149) · 99% of runs with a Sandpiper profile · first public 2025-11-23
Authors (13)
Zhao Y first · Chen J · Zhu S · Xu Y · Zhu J · Yang J · Zhou W · Yang Y · Lin M · Chen Q · Xia M · Chen Y · Liu Y last
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA1214590.csv.gz (4.7 KB) · parquet (76.5 KB) — all 149 samples, every field with route and confidence · PRJNA1214590_determinations.csv.gz (7.1 KB) — 1,043 evidence rows