Gut microbiota probiotic intervention in MCI, Cordoba, Spain
1 sample from Cordoba, Spain, part of an intervention study testing a probiotic treatment's effect on gut microbiota in relation to mild cognitive impairment. machine-written summary
358 samples · 358 runs · Adult · 2025 · 4.34 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ○ Sequence archive | records read; no usable sample values |
| ✓ Abstract / description | 716 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Probiotic (live microorganisms; single strain or mixture) design randomized_controlled_trial · population neurological_psychiatric · Diet and/or probiotic treatment in MCI patients
“effect of diet and/or a probiotic treatment on the gut-microbiota” — bioproject.description (study level; per-sample arms are in the intervention column below)
Genera, mean relative abundance over 1 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 0 | 0% | ||||
| health_condition | 358 | 100% | 358 | |||
| subject_id | 0 | 0% | ||||
| health_condition_detail | 358 | 100% | 358 |
- Shotgun metagenomics data from faecal samples of 47 patients with mild cognitive impairment: Insights from the memoir study 2025 own_data
Archive description
Mild Cognitive Impairment (MCI) is a syndrome that encompasses decline in some mental abilities including memory, perception and language domains. It has been hypothesised that the syndrome may be triggered by intestinal dysfunction. In fact, the microbial-gut-brain axis, a feedback mechanism between the gut microbiota and the central nervous system, has been previously associated with senescence and neuropsychiatric diseases. Our project aims to determine the effect of diet and/or a probiotic treatment on the gut-microbiota and its association with MCI.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by sonnet_x2 with confidence 0.53. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
- life stage study.description · “previously associated with senescence”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SRR32235952 | health_condition | neurological_psychiatric | R4 | 0.50 | paper.abstract | individuals over the age of 65 diagnosed with mild cognitive impairment (MCI) |
| SRR32235952 | health_condition_detail | mild cognitive impairment (MCI) | R4 | 0.50 | paper.abstract | individuals over the age of 65 diagnosed with mild cognitive impairment (MCI) |
Sequencing
358 runs over 358 samples · mean 5.20 Gbp per run (median 4.34 Gbp, total 1,861.42 Gbp; 358 runs with a base count) · layout SINGLE 358 · platform ILLUMINA 358 · models Illumina NovaSeq 6000 (358) · 90% of runs with a Sandpiper profile · first public 2025-02-08
Authors (0)
No author record.
Help complete this project
3 of the 4 core fields are below 50% coverage: age_category, country, subject_id. Share metadata
Downloads
PRJNA1219367.csv.gz (6.8 KB) · parquet (76.8 KB) — all 358 samples, every field with route and confidence · PRJNA1219367_determinations.csv.gz (3.2 KB) — 716 evidence rows