Gut microbiota in Alzheimer's vs healthy controls, Shantou, China

Plasma Exosomal miRNA Expression and Gut Microbiota Dysbiosis Are Associated with Cognitive Impairment in Alzheimer's Disease.

16 samples from Shantou, China, in a case-control study comparing gut microbiota and plasma exosomal miRNAs between participants with Alzheimer's disease and those with normal cognition. machine-written summary

16 samples · 16 runs · CN · Elderly · 2025 · 6.64 Gbp / sample

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Sources

✓Sequence archive 160○Abstract / description✓Full text 48○Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave

✓ Sequence archive	160 sample values (age, country, health condition, health condition detail, latitude, location locality, location region, longitude)
○ Abstract / description	read; no usable statement
✓ Full text	48 sample values (antibiotic exposure, collection date, location site) · PMC11880238
○ Supplementary tables	files read; no table could be matched to the samples
– External resources	not covered by the external resources we ingest
– User contribution	nothing uploaded yet
– Human verified	not yet checked by a person · I checked this project — verify it

Samples at a glance

1 sampling locations · 1 country

Age

elderly11

adult5

Condition

healthy_control8

neurological_psychiatric8

Sex

female12

male4

Country

CN16

Body site

primary16

Sequencing depth per sample · this project all projects

Community composition

Phocaeicola 14.3%Bacteroides 10.6%Prevotella 10.5%Faecalibacterium 6.9%Alistipes 5.7%Roseburia 4.7%Blautia_A 2.2%Lachnospira 2.0%Megamonas 1.7%Acetatifactor 1.5%Mediterraneibacter 1.4%Parabacteroides 1.4%not assigned to a genus 3.8%other genera 33.3%

Genera, mean relative abundance over 12 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage

field	samples	coverage	R1	R3
age_category	16	100%
country	16	100%	16
health_condition	16	100%	16
subject_id	16	100%	16
age_at_collection_days	16	100%	16
antibiotic_exposure	16	100%		16
collection_date	16	100%		16
detailed_location	16	100%
health_condition_detail	16	100%	16
latitude	16	100%	16
location_locality	16	100%	16
location_region	16	100%	16
location_site	16	100%		16
longitude	16	100%	16
sex	16	100%	16

Papers (1)

Plasma exosomal miRNA expression and gut microbiota dysbiosis are associated with cognitive impairment in Alzheimer's disease. 2025 PMID 40046438 PMC11880238 own_data

Details

Archive description

The gut microbiota composition and the expression profiles of microRNAs (miRNAs) in the brain tissue, cerebrospinal fluid, and blood of patients with Alzheimer's disease (AD) differ significantly from those with normal cognition function. The study aimed to initially explore the relationship between plasma exosomal microRNAs, gut microbiota, and cognitive impairment, providing insights into the pathogenesis and treatment of AD.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of elderly and adult by sonnet_x2 with confidence 0.75. Assay shotgun_dna.

host run.host_tax_id · “9606”
body site run.scientific_name · “human gut metagenome”
life stage sample.attr.host_age · “69 years old (n=13/16)”
life stage sample.attr.host_age · “52 years old (n=3/16)”

Evidence examples (one per field × route)

sample	field	value	route	conf.	source	quote
SAMN46737004	age_at_collection_days	25568.0	R1	0.90	sample.attr.host_age	70 years old
SAMN46737004	antibiotic_exposure	no	R3	0.70	paper.fulltext.methods	no use of probiotics, antibiotics, or proton pump inhibitors in the past
SAMN46737004	collection_date	2021-01/2022-10	R3	0.70	paper.fulltext.methods	January 2021 to October 2022
SAMN46737004	country	CN	R1	0.90	sample.attr.geo_loc_name	China: Shantou
SAMN46737004	health_condition	neurological_psychiatric	R1	0.90	biosample_attr	Alzheimer's Disease
SAMN46737004	health_condition_detail	Alzheimer's Disease	R1	0.90	sample.attr.host_disease	Alzheimer's Disease
SAMN46737004	latitude	23.3500	R1	0.90	biosample.attribute:lat_lon	23.35 N 116.68 E
SAMN46737004	location_locality	Shantou	R1	0.85	biosample.attribute:geo_loc_name	China: Shantou
SAMN46737004	location_region	Guangdong	R1	0.60	biosample.attribute:lat_lon	23.35 N 116.68 E
SAMN46737004	location_site	First Affiliated Hospital of Shantou University Medical College	R3	0.70	paper.fulltext.methods	First Affiliated Hospital of Shantou University Medical College from January 2021
SAMN46737004	longitude	116.6800	R1	0.90	biosample.attribute:lat_lon	23.35 N 116.68 E
SAMN46737004	sex	female	R1	0.90	sample.attr.host_sex	female
SAMN46737004	subject_id	AD01	R1	0.85	sample.attr.host_subject_id	AD01

Sequencing

16 runs over 16 samples · mean 6.69 Gbp per run (median 6.64 Gbp, total 107.06 Gbp; 16 runs with a base count) · layout PAIRED 16 · platform ILLUMINA 16 · models Illumina NovaSeq 6000 (16) · 75% of runs with a Sandpiper profile · first public 2025-02-15

Authors (6)

Lin K first · Lin W · Guo Z · Chen C · Chen L · Cai X last

Downloads

PRJNA1221292.csv.gz (1.5 KB) · parquet (72.2 KB) — all 16 samples, every field with route and confidence · PRJNA1221292_determinations.csv.gz (2.4 KB) — 208 evidence rows

Samples (16 · every field this project has values for · hover a cell for its source)

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