Gut metagenomics in ARN and VKH patients vs controls, Changchun
30 fecal samples from adults in Changchun, China, comparing acute retinal necrosis (and Vogt-Koyanagi-Harada disease) patients to healthy controls in a case-control study of gut bacteriome and virome. machine-written summary
30 samples · 30 runs · CN · Adult · 2026 · 11.13 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 237 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| ✓ Abstract / description | 30 sample values (subject id) |
| ✓ Full text | 60 sample values (antibiotic exposure, location site) · PMC12147045, PMC13357178 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 30 | 100% | ||||
| country | 30 | 100% | 30 | |||
| health_condition | 30 | 100% | 30 | |||
| subject_id | 30 | 100% | 30 | |||
| antibiotic_exposure | 30 | 100% | 30 | |||
| collection_date | 30 | 100% | 30 | |||
| detailed_location | 30 | 100% | ||||
| health_condition_detail | 30 | 100% | 30 | |||
| latitude | 30 | 100% | 30 | |||
| location_locality | 30 | 100% | 30 | |||
| location_site | 30 | 100% | 30 | |||
| longitude | 30 | 100% | 30 | |||
| location_region | 27 | 90% | 27 |
- Alterations of the Enteric Virome in Vogt-Koyanagi-Harada Disease. 2025 PMID 40465264 PMC12147045 own_data
- Remodeling of gut bacteriome and virome in acute retinal necrosis: expansion of <i>Enterobacteriaceae</i>-related taxa. 2026 PMID 42445487 PMC13357178 own_data
Archive description
Metagenomics sequence reads of fecal samples collected from patients with Vogt-Koyanagi-Harada disease and acute retinal necrosis who visited the Department of Ophthalmology, the Second Hospital of Jilin University, compared to healthy controls.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Fecal metagenomics analysis of”
- body site study.description · “sequence reads of fecal samples collected from”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN46880268 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | not received any medications, including antibiotics or supplements, within 6 months |
| SAMN46880268 | collection_date | 2023-09-26 | R1 | 0.90 | biosample.attribute:collection_date | 2023-09-26T09:32:50Z |
| SAMN46880268 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: changchun |
| SAMN46880268 | health_condition | autoimmune_inflammatory | R1 | 0.70 | sample.name_rule:alias | VKH1 |
| SAMN46880268 | health_condition_detail | VKH | R1 | 0.70 | sample.name_rule:alias | VKH1 |
| SAMN46880268 | latitude | 43.8800 | R1 | 0.90 | biosample.attribute:lat_lon | 43.88 N 125.33 E |
| SAMN46880268 | location_locality | Changchun | R1 | 0.85 | biosample.attribute:geo_loc_name | China: changchun |
| SAMN46880268 | location_region | Jilin Sheng | R1 | 0.60 | biosample.attribute:lat_lon | 43.88 N 125.33 E |
| SAMN46880268 | location_site | Second Hospital of Jilin University | R3 | 0.70 | paper.fulltext.methods | visited the Department of Ophthalmology, the Second Hospital of Jilin University |
| SAMN46880268 | longitude | 125.3300 | R1 | 0.90 | biosample.attribute:lat_lon | 43.88 N 125.33 E |
| SAMN46880268 | subject_id | SAMN46880268 | R4 | 0.60 | design.one_sample_per_subject:abstract | The gut virome and bacteriome of 10 patients with new-onset ARN and 10 age- and sex-matched healthy individuals (N) were profiled |
Sequencing
30 runs over 30 samples · mean 11.24 Gbp per run (median 11.13 Gbp, total 337.06 Gbp; 30 runs with a base count) · layout PAIRED 30 · platform ILLUMINA 30 · models Illumina NovaSeq 6000 (30) · 0% of runs with a Sandpiper profile · first public 2026-06-20 – 2026-07-19
Downloads
PRJNA1225217.csv.gz (2.0 KB) · parquet (72.4 KB) — all 30 samples, every field with route and confidence · PRJNA1225217_determinations.csv.gz (4.1 KB) — 327 evidence rows