Gut metagenome in Chinese adolescents, stress, longitudinal
102 stool metagenome samples from adolescents in Xi'an, China, collected at baseline and follow-up to study links between psychological stress, gut microbiota, and fecal metabolites. machine-written summary
102 samples · 102 runs · CN · Adolescent · 2025 · 3.47 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 612 sample values (collection date, country, latitude, location locality, location region, longitude) |
| ✓ Abstract / description | 102 sample values (health condition detail) |
| ✓ Full text | 204 sample values (antibiotic exposure, location site) · PMC12612998 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
Schedule stated by the source: “Stool collected at baseline (2022) and at follow-up, over a 2-year follow-up period” (time origin: enrolment).
Genera, mean relative abundance over 101 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 102 | 100% | ||||
| country | 102 | 100% | 102 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| antibiotic_exposure | 102 | 100% | 102 | |||
| collection_date | 102 | 100% | 102 | |||
| detailed_location | 102 | 100% | ||||
| health_condition_detail | 102 | 100% | 102 | |||
| latitude | 102 | 100% | 102 | |||
| location_locality | 102 | 100% | 102 | |||
| location_region | 102 | 100% | 102 | |||
| location_site | 102 | 100% | 102 | |||
| longitude | 102 | 100% | 102 |
- The interactions between psychological stress, gut microbiota, and fecal metabolites: A longitudinal multi-omics study in Chinese adolescents. 2025 PMID 41246284 PMC12612998 own_data
Archive description
Fifty-one adolescents were followed up for 2 years and their stool samples were collected for macrogene sequencing
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adolescent by sonnet_x2 with confidence 0.72. Assay shotgun_dna.
- host study.title · “Homo sapiens Raw sequence reads”
- body site study.description · “stool samples were collected”
- life stage study.description · “Fifty-one adolescents were followed up”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN46957998 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | history of digestive system diseases or antibiotics |
| SAMN46957998 | collection_date | 2023-11-01 | R1 | 0.90 | biosample.attribute:collection_date | 2023-11-01T14:41:36Z |
| SAMN46957998 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Xi 'an |
| SAMN46957998 | health_condition_detail | mixed_case_control: Cohort stratified by stress levels (high vs low); no indication all subjects share a single health c | R4 | 0.50 | paper.abstract | adolescents with high versus low stress |
| SAMN46957998 | latitude | 34.2600 | R1 | 0.90 | biosample.attribute:lat_lon | 34.26 N 108.85 E |
| SAMN46957998 | location_locality | Xi'an | R1 | 0.75 | biosample.attribute:geo_loc_name | China:Xi 'an |
| SAMN46957998 | location_region | Shaanxi | R1 | 0.60 | biosample.attribute:lat_lon | 34.26 N 108.85 E |
| SAMN46957998 | location_site | Fengxi Middle School | R3 | 0.70 | paper.fulltext.methods | recruited 124 adolescents aged 12–16 years at baseline in 2022 from Fengxi |
| SAMN46957998 | longitude | 108.8500 | R1 | 0.90 | biosample.attribute:lat_lon | 34.26 N 108.85 E |
Sequencing
102 runs over 102 samples · mean 3.55 Gbp per run (median 3.47 Gbp, total 361.74 Gbp; 102 runs with a base count) · layout SINGLE 102 · platform ILLUMINA 102 · models Illumina NovaSeq 6000 (102) · 99% of runs with a Sandpiper profile · first public 2025-03-09
Authors (13)
Yang C first · Lv M · Li Y · He Y · Zhang S · Zhang G · Lan J · Guo Z · Cheng Y · Yang Y · Sun J · Ma L · Zhang L last
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJNA1226748.csv.gz (3.3 KB) · parquet (74.7 KB) — all 102 samples, every field with route and confidence · PRJNA1226748_determinations.csv.gz (6.6 KB) — 918 evidence rows