Gut metagenomes in R/R-DLBCL patients on CAR-T therapy, Seoul
89 longitudinal stool/serum shotgun metagenome samples from relapsed/refractory DLBCL patients in Seoul, Korea, collected around CAR-T cell therapy to study gut microbiome links to treatment response and toxicity. machine-written summary
89 samples · 89 runs · KR · Adult · 2025 · 10.64 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 623 sample values (age, collection date, country, latitude, location region, longitude, subject id) |
| ✓ Abstract / description | 178 sample values (health condition, health condition detail) |
| ○ Full text | read; no usable statement or table · PMC12955626 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
33 of 56 people sampled more than once (66 samples; median 2, up to 2 per person). Schedule stated by the source: “Fecal/serum collected at baseline before apheresis (pretreatment, n=47) and 1 month after CAR T-cell infusion (posttreatment, n=32)”; stated follow-up 30 d.
Genera, mean relative abundance over 85 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 89 | 100% | ||||
| country | 89 | 100% | 89 | |||
| health_condition | 89 | 100% | 89 | |||
| subject_id | 89 | 100% | 89 | |||
| age_at_collection_days | 89 | 100% | 89 | |||
| collection_date | 89 | 100% | 89 | |||
| detailed_location | 89 | 100% | ||||
| health_condition_detail | 89 | 100% | 89 | |||
| latitude | 89 | 100% | 89 | |||
| location_region | 89 | 100% | 89 | |||
| longitude | 89 | 100% | 89 |
- Microbiome and metabolite biomarkers of CAR T-cell therapy outcomes in relapsed/refractory diffuse large B-cell lymphoma. 2026 PMID 41364878 PMC12955626 own_data
Archive description
Gut microbiome shotgun metagenome data from DLBCL patients receiving CAR-T therapy
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Gut microbiome shotgun metagenome”
- body site study.description · “Gut microbiome shotgun metagenome”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage sample.attr.host_age · “71 (n=23/89)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN47141066 | age_at_collection_days | 22627.0 | R1 | 0.85 | sample.attr.host_age | 62 |
| SAMN47141066 | collection_date | 2023-09-01 | R1 | 0.90 | biosample.attribute:collection_date | 2023-09-01 |
| SAMN47141066 | country | KR | R1 | 0.90 | sample.attr.geo_loc_name | Korea: Seoul |
| SAMN47141066 | health_condition | other_disease | R4 | 0.50 | paper.abstract | patients with R/R-DLBCL |
| SAMN47141066 | health_condition_detail | relapsed/refractory diffuse large B-cell lymphoma | R4 | 0.50 | paper.abstract | relapsed/refractory diffuse large B-cell lymphoma (R/R-DLBCL) |
| SAMN47141066 | latitude | 37.4800 | R1 | 0.90 | biosample.attribute:lat_lon | 37.48 N 127.09 E |
| SAMN47141066 | location_region | Seoul | R1 | 0.85 | biosample.attribute:geo_loc_name | Korea: Seoul |
| SAMN47141066 | longitude | 127.0900 | R1 | 0.90 | biosample.attribute:lat_lon | 37.48 N 127.09 E |
| SAMN47141066 | subject_id | 052 | R1 | 0.70 | sample.name_rule:alias | alias: SMCYSE-RD-052-1 |
Sequencing
89 runs over 89 samples · mean 10.93 Gbp per run (median 10.64 Gbp, total 972.61 Gbp; 89 runs with a base count) · layout PAIRED 89 · platform ILLUMINA 89 · models Illumina NovaSeq X (89) · 96% of runs with a Sandpiper profile · first public 2025-03-02 – 2025-03-03
Authors (17)
Yoon SE first · Kang W · Cho J · Cho HJ · Chalita M · Oh HS · Hyun DW · Han S · Kim H · Sung H · Lee JY · Park B · Ryu KJ · Kim HY · Cho D · Kim WS · Kim SJ last
Downloads
PRJNA1229669.csv.gz (3.5 KB) · parquet (74.4 KB) — all 89 samples, every field with route and confidence · PRJNA1229669_determinations.csv.gz (6.4 KB) — 801 evidence rows