Long COVID gut microbiome in Montreal, Quebec adults
182 gut microbiome samples from adults and elderly individuals in Montreal, Quebec, studying intestinal dysbiosis and gut permeability in long COVID, in a cross-sectional design. machine-written summary
182 samples · 182 runs · CA · Adult · 2025 · 2.78 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,447 sample values (age, country, health condition, health condition detail, location locality, location region, sex, subject id) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
50 of 122 people sampled more than once (101 samples; median 2, up to 3 per person). Schedule stated by the source: “disease_stage: VISITE(3-6 MONTHS) and VISITE(12 MONTHS) for COVIDPOS; single COVIDNEG visit” (time origin: diagnosis).
Genera, mean relative abundance over 174 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 182 | 100% | ||||
| country | 182 | 100% | 182 | |||
| health_condition | 182 | 100% | 182 | |||
| subject_id | 173 | 95% | 173 | |||
| age_at_collection_days | 182 | 100% | 182 | |||
| detailed_location | 182 | 100% | ||||
| health_condition_detail | 182 | 100% | 182 | |||
| location_locality | 182 | 100% | 182 | |||
| location_region | 182 | 100% | 182 | |||
| sex | 182 | 100% | 182 |
- Microbiota-derived extracellular vesicles mediate gut-brain axis dysfunction in long COVID 2026 own_data
- Microbiota-derived extracellular vesicles link intestinal dysbiosis to neuroimmune activation in long COVID 2026 own_data
Archive description
Long COVID (LC) is a debilitating condition that can follow acute SARS-CoV-2 infection. It manifests differently across individuals, but the most severe cases are often associated with neuroinflammation and neuropsychological sequelae. It is known that dysbiosis and leaky gut are also associated with this disease
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by sonnet_x2 with confidence 0.78. Assay shotgun_dna.
- host run.scientific_name · “Homo sapiens”
- body site study.description · “dysbiosis and leaky gut are also associated”
- life stage sample.attr.age · “55 (n=147/182)”
- life stage sample.attr.age · “62 (n=35/182)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN47400862 | age_at_collection_days | 26298.0 | R1 | 0.70 | sample.attr.age | 72 |
| SAMN47400862 | country | CA | R1 | 0.90 | sample.attr.geo_loc_name | Canada: Quebec, Montreal |
| SAMN47400862 | health_condition | other_infection | R1 | 0.85 | biosample_attr | COVIDPOS |
| SAMN47400862 | health_condition_detail | COVIDPOS | R1 | 0.90 | sample.attr.disease | COVIDPOS |
| SAMN47400862 | location_locality | Montreal | R1 | 0.85 | biosample.attribute:geo_loc_name | Canada: Quebec, Montreal |
| SAMN47400862 | location_region | Quebec | R1 | 0.85 | biosample.attribute:geo_loc_name | Canada: Quebec, Montreal |
| SAMN47400862 | sex | female | R1 | 0.90 | sample.attr.sex | female |
| SAMN47400862 | subject_id | 102 | R1 | 0.70 | sample.name_rule:library_name | 102v12m |
Sequencing
182 runs over 182 samples · mean 3.05 Gbp per run (median 2.78 Gbp, total 554.56 Gbp; 182 runs with a base count) · layout PAIRED 182 · platform ILLUMINA 182 · models Illumina NovaSeq 6000 (182) · 96% of runs with a Sandpiper profile · first public 2025-03-16
Authors (0)
No author record.
Downloads
PRJNA1236664.csv.gz (5.9 KB) · parquet (77.6 KB) — all 182 samples, every field with route and confidence · PRJNA1236664_determinations.csv.gz (9.3 KB) — 1,447 evidence rows