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PRJNA1241450 SRP572809

Fecal Microbiota in Adults on Oral Antibiotics, Columbus, USA

Oral Antibiotic Human Case Study

Intervention study of 3 fecal samples from adult patients with other infection taking oral antibiotics, collected in Columbus, USA. machine-written summary

3 samples · 3 runs · US · Adult · 2025 · 4.36 Gbp / sample

Sources
✓Sequence archive 42–Abstract / description–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive42 sample values (age, antibiotic exposure, collection date, country, health condition, health condition detail, intervention, latitude)
– Abstract / descriptionno abstract or project description
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Interventions

intervention · arms resolved

before · no interventionbefore · no interventi1 samplesantibioticantibiotic2 samples
single arm: samples before and on the intervention

1 people have samples in more than one arm.

design single_arm_before_after

Samples at a glance
1 sampling locations · 1 country
Age
adult3
Condition
other_infection3
Sex
female3
Country
US3
Body site
primary3
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 3 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)all projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 4.36 Gbp per sample0130Gbp
Sampling design and relatedness

longitudinal

1 of 1 people sampled more than once (3 samples; median 3, up to 3 per person) · follow-up median 9 d (max 9 d) · median interval between samples 4 d (time from collection dates). Schedule stated by the source: “One subject sampled 3 times: baseline (pre-drug), 3 days post-drug, and 7 days post-drug (oral azithromycin).”.

CC: day 0C: day 5C: day 90 d2 d4 d7 d9 d

Each row is one person (1 shown); dots are samples at days since that person's first sample.

How longitudinal and relatedness information is derived

Community composition
Blautia_A 20.6%Phocaeicola 12.5%Bacteroides 11.7%Mediterraneibacter 11.3%Enterocloster 7.7%Anaerostipes 4.6%Veillonella 3.9%Longicatena 2.7%Faecalimonas 2.7%Streptococcus 2.3%Blautia 2.1%Eggerthella 1.7%not assigned to a genus 4.1%other genera 12.1%

Genera, mean relative abundance over 3 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category3 100%
country3 100%3
health_condition3 100%3
subject_id3 100%3
age_at_collection_days3 100%3
antibiotic_exposure3 100%3
collection_date3 100%3
detailed_location3 100%
health_condition_detail3 100%3
intervention3 100%3
latitude3 100%3
location_locality3 100%3
location_region3 100%3
longitude3 100%3
sex3 100%3
timepoint_label3 100%3
Details
Archive description

Fecal microbiota high throughput sequencing data of human patients taking oral antibiotics.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.75. Assay shotgun_dna.

  • host study.description · “human patients taking oral antibiotics”
  • host run.host_tax_id · “9606”
  • body site study.description · “Fecal microbiota high throughput sequencing”
  • body site run.scientific_name · “human gut metagenome”
  • life stage sample.attr.host_age · “25 to 30 (n=3/3)”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN47555863age_at_collection_days9958.0R10.85sample.attr.host_age25 to 30
SAMN47555863antibiotic_exposurenoR10.70sample.name_rule:titleBaseline_Shotgun_16S
SAMN47555863collection_date2021-12-09R10.90biosample.attribute:collection_date2021-12-09
SAMN47555863countryUSR10.90sample.attr.geo_loc_nameUSA: Columbus
SAMN47555863health_conditionother_infectionR10.85biosample_attrurogenital infection
SAMN47555863health_condition_detailurogenital infectionR10.90sample.attr.host_diseaseurogenital infection
SAMN47555863interventionno_interventionR10.70sample.name_rule:titleBaseline_Shotgun_16S
SAMN47555863latitude40.0500R10.90biosample.attribute:lat_lon40.05 N 83.05 W
SAMN47555863location_localityColumbusR10.85biosample.attribute:geo_loc_nameUSA: Columbus
SAMN47555863location_regionOhioR10.60biosample.attribute:lat_lon40.05 N 83.05 W
SAMN47555863longitude-83.0500R10.90biosample.attribute:lat_lon40.05 N 83.05 W
SAMN47555863sexfemaleR10.90sample.attr.host_sexfemale
SAMN47555863subject_idCR10.85sample.attr.host_subject_idC
SAMN47555863timepoint_labelBaseline_Shotgun_16SR10.70sample.name_rule:titleBaseline_Shotgun_16S
Sequencing

3 runs over 3 samples · mean 4.28 Gbp per run (median 4.36 Gbp, total 12.85 Gbp; 3 runs with a base count) · layout PAIRED 3 · platform ILLUMINA 3 · models NextSeq 2000 (3) · 100% of runs with a Sandpiper profile · first public 2025-09-01

Authors (0)

No author record.

Downloads

PRJNA1241450.csv.gz (1.0 KB) · parquet (71.3 KB) — all 3 samples, every field with route and confidence · PRJNA1241450_determinations.csv.gz (1.2 KB) — 42 evidence rows

Samples (3 · every field this project has values for · hover a cell for its source)
Loading the sample table…