Pediatric IBD multiomic gut microbiome study, Phoenix, AZ
30 gut microbiome samples from children and adolescents in Phoenix, Arizona, with ulcerative colitis, Crohn's disease, other disease, or healthy controls, analyzed via shotgun metagenomics, metatranscriptomics, and 16S rRNA sequencing; cross-sectional design. machine-written summary
30 samples · 30 runs · US · Infant / toddler · 2026 · 7.20 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 179 sample values (age, collection date, country, health condition, health condition detail, sex) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 60 sample values (antibiotic exposure, location site) · PMC12109367 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 30 | 100% | ||||
| country | 30 | 100% | 30 | |||
| health_condition | 29 | 97% | 29 | |||
| subject_id | 0 | 0% | ||||
| age_at_collection_days | 30 | 100% | 30 | |||
| antibiotic_exposure | 30 | 100% | 30 | |||
| collection_date | 30 | 100% | 30 | |||
| detailed_location | 30 | 100% | ||||
| health_condition_detail | 30 | 100% | 30 | |||
| location_site | 30 | 100% | 30 | |||
| sex | 30 | 100% | 30 |
- Multiomics-Based Profiling of the Fecal Microbiome Reveals Potential Disease-Specific Signatures in Pediatric IBD (PIBD). 2025 PMID 40427639 PMC12109367 own_data
Archive description
The pathophysiology of IBD is incompletely understood, and diagnostic biomarkers and effective treat-ments, particularly for PIBD, are limited. Recent work suggests that these factors may interact to influence disease development, and multiomic approaches have emerged as promising tools. We employed a multiomic approach to examine the microbiome, its genetic potential, and its activity (as measured by metabolomics- and metatranscriptomics-based approaches) to identify factors associated with PIBD.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and child by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site external_curation.infant_catalog · “infant triage verdict include (gut/stool scope)”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.title · “Pediatric IBD Shotgun Metagenomics,”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN47569472 | age_at_collection_days | 6209 | R1 | 0.70 | sample.attr.host_age | 17 |
| SAMN47569472 | antibiotic_exposure | no | R3 | 0.70 | paper.body.methods_results | Patients who had been exposed to antibiotics or had a bowel cleanout over the past 30 days |
| SAMN47569472 | collection_date | 2021-05-02 | R1 | 0.85 | biosample.attribute:collection_date | collection_date: 2021-05-02 |
| SAMN47569472 | country | US | R1 | 0.90 | biosample_attr | USA: Phoenix, Arizona |
| SAMN47569472 | health_condition | crohns_disease | R1 | 0.80 | biosample.attribute:gastrointest_disord | gastrointest_disord: Crohn's Disease - Naive |
| SAMN47569472 | health_condition_detail | Crohn's Disease - Naive | R1 | 0.90 | biosample.attribute:gastrointest_disord | gastrointest_disord: Crohn's Disease - Naive |
| SAMN47569472 | location_site | Phoenix Children's Hospital | R3 | 0.70 | paper.body.methods_results | Phoenix Children’s Hospital |
| SAMN47569472 | sex | female | R1 | 0.90 | biosample_attr | female |
Sequencing
30 runs over 30 samples · mean 7.48 Gbp per run (median 7.20 Gbp, total 224.34 Gbp; 30 runs with a base count) · layout PAIRED 30 · platform ILLUMINA 30 · models Illumina NovaSeq 6000 (30) · 0% of runs with a Sandpiper profile · first public 2026-04-19
Authors (0)
No author record.
Downloads
PRJNA1241499.csv.gz (2.1 KB) · parquet (71.7 KB) — all 30 samples, every field with route and confidence · PRJNA1241499_determinations.csv.gz (3.0 KB) — 239 evidence rows