Trichuriasis gut microbiota: Côte d'Ivoire, Laos, Tanzania
790 gut metagenome samples from three trichuriasis-endemic regions (Côte d'Ivoire, Laos, Tanzania), comparing microbiota composition and function between Trichuris trichiura-infected and uninfected individuals. machine-written summary
790 samples · 790 runs · LA, CI, TZ · Age unknown · 2026 · 2.42 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 524 sample values (country) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 788 sample values (subject id) · PMC12902057 |
| ✓ Supplementary tables | 1,102 sample values (country, health condition, health condition detail) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 790 | 100% | 524 | 266 | ||
| health_condition | 418 | 53% | 418 | |||
| subject_id | 788 | 100% | 788 | |||
| health_condition_detail | 418 | 53% | 418 |
- Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns. 2026 PMID 41565669 PMC12902057 cites_accession
Archive description
This study aimed to systematically characterize the taxonomic, functional, and ecological impacts of Trichuris trichiura infection on the human gut microbiota across diverse geographic regions - Cote d Ivoire, Laos, and Tanzania - using unified, high-resolution shotgun metagenomics. As the only soil-transmitted helminth colonizing the large intestine, T. trichiura represents a unique model for investigating helminth-microbiota interactions. The study identifies consistent microbiome alterations, including reduced short-chain fatty acid (SCFA)-producing bacteria and increased mucin-degrading taxa, which may compromise gut barrier integrity and modulate immunity. Additionally, the analysis highlights both shared and region-specific microbiota patterns, illustrating that T. trichiura imposes predictable metabolic pressures independent of geographic variability, with implications for natural immunity and parasite persistence. These findings advance our understanding of helminth-induced dysbiosis, providing critical insights to inform microbiome-based therapeutic interventions and global public health strategies against widespread helminth infections.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.75. Assay shotgun_dna.
- host study.description · “Trichuris trichiura infection on the human gut microbiota”
- body site study.title · “gut microbiota alterations associated with trichuriasis”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN47577592 | country | CI | R1 | 0.85 | biosample.attribute:geo_loc_name | Cote d'Ivoire: Dabou and Jacqueville districts |
| SAMN47577642 | country | CI | R2 | 0.80 | paper.supp.41522_2026_911_MOESM2_ESM.xlsx[Data 1!Country] | Country: Côte d'Ivoire |
| SAMN47577750 | health_condition | gi_infection_or_diarrhoea | R2 | 0.80 | paper.supp.41522_2026_911_MOESM2_ESM.xlsx[Data 1!Infection_status_Trichuris] | Infection_status_Trichuris: Positive |
| SAMN47577750 | health_condition_detail | Positive | R2 | 0.80 | paper.supp.41522_2026_911_MOESM2_ESM.xlsx[Data 1!Infection_status_Trichuris] | Infection_status_Trichuris: Positive |
| SAMN47577592 | subject_id | SAMN47577592 | R3 | 0.70 | design.one_sample_per_subject:fulltext | 9/799 samples included in this study were dropped due to insufficient sequencing quality. |
Sequencing
790 runs over 790 samples · mean 2.46 Gbp per run (median 2.42 Gbp, total 1,939.86 Gbp; 790 runs with a base count) · layout PAIRED 790 · platform ILLUMINA 790 · models Illumina NovaSeq 6000 (790) · 0% of runs with a Sandpiper profile · first public 2026-02-22
Authors (0)
No author record.
Downloads
PRJNA1242044.csv.gz (19.8 KB) · parquet (103.1 KB) — all 790 samples, every field with route and confidence · PRJNA1242044_determinations.csv.gz (16.1 KB) — 2,414 evidence rows