Gut metagenome in MS patients vs healthy donors, Italy
Case-control study of 89 gut metagenome samples from treatment-naive and treated Multiple Sclerosis patients and healthy donors, collected across sites in Piemonte, Campania, and Lombardia, Italy. machine-written summary
89 samples · 89 runs · IT · Age unknown · 2025 · 12.75 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 708 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 88 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 89 | 100% | 89 | |||
| health_condition | 87 | 98% | 87 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 89 | 100% | 89 | |||
| detailed_location | 89 | 100% | ||||
| latitude | 89 | 100% | 89 | |||
| location_locality | 89 | 100% | 89 | |||
| location_region | 89 | 100% | 89 | |||
| longitude | 89 | 100% | 89 | |||
| health_condition_detail | 87 | 98% | 87 |
- Gut microbiome profiling at multiple sclerosis onset as a potential early prognostic marker of disease course: evidence from an observational cohort study. 2026 PMID 42700718 own_data
Archive description
This study analyzed the gut metagenome of 53 treatment-naive Multiple Sclerosis (MS), 11 treated-MS patients and 18 healthy donors using shotgun metagenomics.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.75. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site study.title · “Gut metagenome of Multiple Sclerosis”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN47761296 | collection_date | 2018-03-08 | R1 | 0.90 | biosample.attribute:collection_date | 2018-03-08 |
| SAMN47761296 | country | IT | R1 | 0.90 | sample.attr.geo_loc_name | Italy:Piemonte,Torino |
| SAMN47761296 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:experiment_title | Metagenomic shotgun sequencing of human gut microbiota: healthy subject - HD01 |
| SAMN47761296 | health_condition_detail | healthy subject | R1 | 0.70 | sample.name_rule:experiment_title | Metagenomic shotgun sequencing of human gut microbiota: healthy subject - HD01 |
| SAMN47761296 | latitude | 45.0291 | R1 | 0.90 | biosample.attribute:lat_lon | 45.02911759 N 7.55767543 E |
| SAMN47761296 | location_locality | Turin | R1 | 0.75 | biosample.attribute:geo_loc_name | Italy:Piemonte,Torino |
| SAMN47761296 | location_region | Piedmont | R1 | 0.75 | biosample.attribute:geo_loc_name | Italy:Piemonte,Torino |
| SAMN47761296 | longitude | 7.5577 | R1 | 0.90 | biosample.attribute:lat_lon | 45.02911759 N 7.55767543 E |
Sequencing
89 runs over 89 samples · mean 13.23 Gbp per run (median 12.75 Gbp, total 1,177.72 Gbp; 89 runs with a base count) · layout PAIRED 89 · platform ILLUMINA 89 · models Illumina NovaSeq X Plus (89) · 99% of runs with a Sandpiper profile · first public 2025-10-23
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, subject_id. Share metadata
Downloads
PRJNA1245671.csv.gz (3.5 KB) · parquet (74.4 KB) — all 89 samples, every field with route and confidence · PRJNA1245671_determinations.csv.gz (6.2 KB) — 708 evidence rows