Gut Metagenomes in Gestational Diabetes/Hypertension, Indiana
73 fecal shotgun metagenome samples from a case-control cohort in Indiana, USA, including adults and 4 neonates, comparing gestational diabetes and gestational hypertension cases to healthy controls (31 samples). machine-written summary
73 samples · 73 runs · US · Adult · 2025 · 2.46 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 797 sample values (age, bmi, collection date, country, health condition, health condition detail, location region, sex) |
| ✓ Abstract / description | 1 sample values (health condition detail) |
| ✓ Full text | 1 sample values (sex) · PMC13141881 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal
14 of 57 people sampled more than once (30 samples; median 2, up to 3 per person) · follow-up median 3 mo (max 7 mo) · median interval between samples 3 mo (time from collection dates). Schedule stated by the source: “Fecal samples collected during mid-to-late gestation across multiple visits (Visit=0,1,2,P); some subjects sampled up to 3 times.”.
Each row is one person (14 shown); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 71 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 73 | 100% | ||||
| country | 73 | 100% | 73 | |||
| health_condition | 73 | 100% | 73 | |||
| subject_id | 73 | 100% | 73 | |||
| age_at_collection_days | 73 | 100% | 73 | |||
| collection_date | 73 | 100% | 73 | |||
| detailed_location | 73 | 100% | ||||
| health_condition_detail | 73 | 100% | 72 | 1 | ||
| location_region | 73 | 100% | 73 | |||
| sex | 73 | 100% | 72 | 1 | ||
| smoking_status | 73 | 100% | 73 | |||
| timepoint_label | 73 | 100% | 73 | |||
| bmi | 69 | 95% | 69 |
- Metagenomic profiling and predictive modeling of the gut microbiome reveal signatures of gestational disease. 2026 PMID 41879323 PMC13141881 own_data
Archive description
This project contains raw shotgun metagenomic sequencing data from fecal samples collected during mid-to-late gestation as part of a study on gut microbiome alterations associated with gestational conditions. Samples were obtained from participants in a prospective observational cohort, including individuals diagnosed with gestational diabetes mellitus (GDM), gestational hypertension (GH), and those with uncomplicated pregnancies. Sequencing was performed on Illumina platforms across two batches. The data were generated to support investigations into microbiome-driven differences in metabolic and immune-related pathways across gestational phenotypes. This dataset underlies the manuscript titled "Metagenomic Profiling and Predictive Modeling Reveal Gut Microbiome Signatures of Gestational Diseases", which identifies differentially abundant microbial taxa and functional pathways, and applies machine learning models to predict gestational disease status based on microbiome profiles.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_maternal_only”
- body site study.title · “Sequences of Host-Associated Gut Microbiomes in Gestational”
- body site study.description · “sequencing data from fecal samples collected during”
- life stage external_curation.infant_catalog · “infant triage reason_code age_maternal_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN47834585 | age_at_collection_days | 14245.0 | R1 | 0.85 | biosample.attribute:consent_age | consent_age: 39 |
| SAMN47834587 | age_at_collection_days | 10215.0 | R1 | 0.85 | sample.attr.consent_age | 28 |
| SAMN47834585 | bmi | 24.64 | R1 | 0.90 | sample.attr.bmi | 24.64 |
| SAMN47834585 | collection_date | 2019-04-18 | R1 | 0.90 | biosample.attribute:collection_date | 2019-04-18 |
| SAMN47834585 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA: Indiana |
| SAMN47834585 | health_condition | healthy_control | R1 | 0.80 | biosample_attr | Control |
| SAMN47834586 | health_condition | pregnancy_postpartum | R1 | 0.85 | biosample.attribute:group | group: Case |
| SAMN47834585 | health_condition_detail | hypertension: no | R1 | 0.85 | sample.attr.hypertension | No |
| SAMN47834642 | health_condition_detail | mixed_case_control: GDM patients vs GH patients vs healthy pregnant controls | R4 | 0.40 | study.description | gestational diabetes mellitus (GDM), gestational hypertension (GH), and those with uncomplicated pregnancies |
| SAMN47834585 | location_region | Indiana | R1 | 0.85 | biosample.attribute:geo_loc_name | USA: Indiana |
| SAMN47834585 | sex | female | R1 | 0.90 | sample.attr.ca_ld_sex_of_baby | Female |
| SAMN47834642 | sex | female | R3 | 0.70 | paper.fulltext.methods | pregnant with a singleton gestation less than 20 weeks |
| SAMN47834585 | smoking_status | never | R1 | 0.70 | biosample.attribute:tobacco_use | 0 |
| SAMN47834585 | subject_id | HMC-01-1006 | R1 | 0.85 | sample.attr.subject_id | HMC-01-1006 |
| SAMN47834585 | timepoint_label | 2 | R1 | 0.85 | sample.attr.visit | 2 |
Sequencing
73 runs over 73 samples · mean 4.21 Gbp per run (median 2.46 Gbp, total 307.31 Gbp; 73 runs with a base count) · layout PAIRED 73 · platform ILLUMINA 73 · models NextSeq 500 (73) · 97% of runs with a Sandpiper profile · first public 2025-04-09 – 2025-04-13
Authors (5)
Mortensen GA first · Schmidt H · Radivojac P · Ye Y · Haas DM last
Downloads
PRJNA1247940.csv.gz (3.8 KB) · parquet (75.7 KB) — all 73 samples, every field with route and confidence · PRJNA1247940_determinations.csv.gz (7.5 KB) — 799 evidence rows