Gut microbiome in rectal cancer patients vs controls
57 longitudinal gut microbiome samples from adults with locally advanced rectal cancer undergoing total neoadjuvant therapy with pelvic irradiation, compared with healthy controls, examining baseline and on-treatment microbiome markers of treatment response. machine-written summary
57 samples · 57 runs · HU · Adult · 2026 · 6.87 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 513 sample values (collection date, country, health condition, health condition detail, intervention, intervention detail, location locality, subject id) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
13 of 31 people sampled more than once (39 samples; median 3, up to 3 per person). Schedule stated by the source: “Samples taken at baseline and on-treatment timepoints during total neoadjuvant therapy with pelvic irradiation, keyed by number_of_dose (0,1,2,3) and sample suffixes _1/_2/_3 per patient (e.g., patien” (time origin: intervention/treatment start).
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 57 | 100% | ||||
| country | 57 | 100% | 57 | |||
| health_condition | 57 | 100% | 57 | |||
| subject_id | 57 | 100% | 57 | |||
| collection_date | 57 | 100% | 57 | |||
| detailed_location | 57 | 100% | ||||
| health_condition_detail | 57 | 100% | 57 | |||
| intervention | 57 | 100% | 57 | |||
| intervention_detail | 57 | 100% | 57 | |||
| location_locality | 57 | 100% | 57 | |||
| timepoint_label | 57 | 100% | 57 |
- Baseline Gut Microbiome Profiling in Therapy-Naive Patients with Locally Advanced Rectal Cancer Identifies Signatures of Response to Total Neoadjuvant Therapy 2026 own_data
Archive description
Total neoadjuvant therapy (TNT) is standard for locally advanced rectal cancer, yet treatment response is biologically heterogeneous, underscoring the need for predictive biomarkers. It is aimed to characterize how baseline and on-treatment gut microbiome ecology relate to clinically relevant response dimensions, and to identify baseline-level markers that could be integrated into a pre-treatment response score.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.72. Assay shotgun_dna.
- host study.title · “Patients with pelvic irradiation”
- body site study.description · “baseline and on-treatment gut microbiome ecology”
- life stage study.description · “locally advanced rectal cancer”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN48116384 | collection_date | 2024 | R1 | 0.90 | biosample.attribute:collection_date | 2024 |
| SAMN48116384 | country | HU | R1 | 0.90 | sample.attr.geo_loc_name | Hungary: Debrecen |
| SAMN48116384 | health_condition | healthy_control | R1 | 0.90 | biosample_attr | healthy |
| SAMN48116402 | health_condition | colorectal_cancer | R1 | 0.85 | biosample.attribute:patient_status | patient_status: disease |
| SAMN48116384 | health_condition_detail | healthy | R1 | 0.90 | sample.attr.patient_status | healthy |
| SAMN48116384 | intervention | no_intervention | R1 | 0.90 | biosample.attribute:number_of_dose | number_of_dose: 0_dose |
| SAMN48116384 | intervention_detail | no treatment doses received (baseline) | R1 | 0.90 | biosample.attribute:number_of_dose | number_of_dose: 0_dose |
| SAMN48116384 | location_locality | Debrecen | R1 | 0.85 | biosample.attribute:geo_loc_name | Hungary: Debrecen |
| SAMN48116384 | subject_id | C1 | R1 | 0.70 | sample.name_rule:library_name | healthy_C1 |
| SAMN48116384 | timepoint_label | 0_dose | R1 | 0.85 | biosample.attribute:number_of_dose | number_of_dose: 0_dose |
Sequencing
57 runs over 57 samples · mean 6.96 Gbp per run (median 6.87 Gbp, total 396.99 Gbp; 57 runs with a base count) · layout PAIRED 57 · platform ILLUMINA 57 · models Illumina NovaSeq 6000 (57) · 0% of runs with a Sandpiper profile · first public 2026-06-17
Authors (0)
No author record.
Downloads
PRJNA1254622.csv.gz (2.4 KB) · parquet (72.1 KB) — all 57 samples, every field with route and confidence · PRJNA1254622_determinations.csv.gz (4.3 KB) — 513 evidence rows