Gut microbiota in frail vs robust older adults, Malaysia
Cross-sectional study of 40 gut microbiome samples from community-dwelling older adults in Selangor, Malaysia, comparing cognitively frail and robust individuals using shotgun metagenomic sequencing. machine-written summary
40 samples · 40 runs · MY · Adult · 2025 · 10.75 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 120 sample values (collection date, country, location region) |
| ✓ Abstract / description | 40 sample values (subject id) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 36 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 40 | 100% | ||||
| country | 40 | 100% | 40 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 40 | 100% | 40 | |||
| collection_date | 40 | 100% | 40 | |||
| detailed_location | 40 | 100% | ||||
| location_region | 40 | 100% | 40 |
Archive description
This study used shotgun metagenomic sequencing to characterize the gut microbiota of 40 community-dwelling older adults. Participants were categorized as either cognitively frail (CF) or robust based on assessments of cognitive and physical function. The study aimed to explore differences in microbial composition and functional pathways between the two groups. Understanding the differences in gut microbiota between CF and robust older adults may provide critical insights into how microbial communities influence the interactions and to understand the potential microbiome related to CF in ageing.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_unknown_no_evidence”
- body site study.title · “genome sequencing of gut microbiota in cognitively”
- body site study.description · “to characterize the gut microbiota of 40”
- life stage study.title · “and robust older adults from the AGELESS”
- life stage study.description · “40 community-dwelling older adults . Participants were”
- life stage study.title · “frail and robust older adults from the AGELESS”
- life stage study.description · “of 40 community-dwelling older adults . Participants were”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN48354801 | collection_date | 2023-10-17 | R1 | 0.90 | biosample.attribute:collection_date | 2023-10-17 |
| SAMN48354801 | country | MY | R1 | 0.90 | sample.attr.geo_loc_name | Malaysia: Selangor |
| SAMN48354801 | location_region | Selangor | R1 | 0.85 | biosample.attribute:geo_loc_name | Malaysia: Selangor |
| SAMN48354801 | subject_id | SAMN48354801 | R4 | 0.60 | design.one_sample_per_subject:description | shotgun metagenomic sequencing to characterize the gut microbiota of 40 community-dwelling older adults |
Sequencing
40 runs over 40 samples · mean 10.56 Gbp per run (median 10.75 Gbp, total 422.52 Gbp; 40 runs with a base count) · layout PAIRED 40 · platform ILLUMINA 40 · models Illumina NovaSeq 6000 (40) · 90% of runs with a Sandpiper profile · first public 2025-06-01
Authors (0)
No author record.
Downloads
PRJNA1258750.csv.gz (2.0 KB) · parquet (70.9 KB) — all 40 samples, every field with route and confidence · PRJNA1258750_determinations.csv.gz (2.1 KB) — 160 evidence rows