Gut metagenome of melanoma patients pre-ICI therapy, Russia
62 pre-treatment fecal samples from adult and elderly melanoma patients in Moscow, Russia, collected in a cross-sectional study examining gut microbiota composition in relation to immune checkpoint inhibitor immunotherapy efficacy. machine-written summary
62 samples · 62 runs · RU · Adult · 2025 · 2.21 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 496 sample values (age, collection date, country, latitude, location locality, location region, longitude, sex) |
| ✓ Abstract / description | 186 sample values (health condition, health condition detail, subject id) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
design observational_with_procedure
Genera, mean relative abundance over 39 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 62 | 100% | ||||
| country | 62 | 100% | 62 | |||
| health_condition | 62 | 100% | 62 | |||
| subject_id | 62 | 100% | 62 | |||
| age_at_collection_days | 62 | 100% | 62 | |||
| collection_date | 62 | 100% | 62 | |||
| detailed_location | 62 | 100% | ||||
| health_condition_detail | 62 | 100% | 62 | |||
| latitude | 62 | 100% | 62 | |||
| location_locality | 62 | 100% | 62 | |||
| location_region | 62 | 100% | 62 | |||
| longitude | 62 | 100% | 62 | |||
| sex | 62 | 100% | 62 |
- Gut microbial markers of immunotherapy response in melanoma: a cross-cohort analysis including the first Russian dataset. 2026 PMID 42298353 PMC13274128 unsure
Archive description
For a correlative study on the effect of the composition of intestinal microbiota on the efficacy of immunotherapy using ICI, 62 pre-treatment fecal samples from adult melanoma patients were recruited.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by sonnet_x2 with confidence 0.85. Assay shotgun_dna.
- host study.title · “Human gut metagenome from melanoma patients”
- body site study.description · “pre-treatment fecal samples from adult melanoma patients”
- life stage study.description · “fecal samples from adult melanoma patients”
- life stage sample.attr.age · “64 (n=23/62)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN49000826 | age_at_collection_days | 17872.0 | R1 | 0.85 | sample.attr.age | 49 |
| SAMN49000826 | collection_date | 2023 | R1 | 0.90 | biosample.attribute:collection_date | 2023 |
| SAMN49000826 | country | RU | R1 | 0.90 | sample.attr.geo_loc_name | Russia: Moscow |
| SAMN49000826 | health_condition | other_cancer | R4 | 0.50 | study.description | adult melanoma patients |
| SAMN49000826 | health_condition_detail | melanoma | R4 | 0.50 | study.description | adult melanoma patients |
| SAMN49000826 | latitude | 55.4500 | R1 | 0.90 | biosample.attribute:lat_lon | 55.45 N 37.37 E |
| SAMN49000826 | location_locality | Moscow | R1 | 0.85 | biosample.attribute:geo_loc_name | Russia: Moscow |
| SAMN49000826 | location_region | Moscow | R1 | 0.85 | biosample.attribute:geo_loc_name | Russia: Moscow |
| SAMN49000826 | longitude | 37.3700 | R1 | 0.90 | biosample.attribute:lat_lon | 55.45 N 37.37 E |
| SAMN49000826 | sex | female | R1 | 0.90 | sample.attr.sex | female |
| SAMN49000826 | subject_id | SAMN49000826 | R4 | 0.65 | design.one_sample_per_subject:description | 62 pre-treatment fecal samples from adult melanoma patients were recruited |
Sequencing
62 runs over 62 samples · mean 2.22 Gbp per run (median 2.21 Gbp, total 137.60 Gbp; 62 runs with a base count) · layout PAIRED 62 · platform ILLUMINA 62 · models NextSeq 1000 (62) · 63% of runs with a Sandpiper profile · first public 2025-06-23 – 2026-01-20
Authors (15)
Strokach A first · Zakharevich N · Aginova V · Grigoryevskaya Z · Petukhova I · Bagirova N · Romanov M · Dyachkova M · Morozov M · Veselovsky V · Kanaeva V · Kalinin D · Larin A · Shitikov E · Klimina K last
Downloads
PRJNA1263414.csv.gz (2.9 KB) · parquet (73.1 KB) — all 62 samples, every field with route and confidence · PRJNA1263414_determinations.csv.gz (4.8 KB) — 682 evidence rows