Gut microbiota and ACEs in pregnant African-American women, USA
Cross-sectional study of 80 stool samples from African-American women in their third trimester of pregnancy in the USA, examining links between adverse childhood experiences, obesity, depression, and gut microbiota. machine-written summary
80 samples · 80 runs · US · Child · 2025 · 3.80 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 880 sample values (antibiotic exposure, bmi, collection date, country, health condition, health condition detail, latitude, location region) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 79 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 80 | 100% | 80 | |||
| health_condition | 80 | 100% | 80 | |||
| subject_id | 80 | 100% | 80 | |||
| antibiotic_exposure | 80 | 100% | 80 | |||
| bmi | 80 | 100% | 80 | |||
| collection_date | 80 | 100% | 80 | |||
| detailed_location | 80 | 100% | ||||
| health_condition_detail | 80 | 100% | 80 | |||
| latitude | 80 | 100% | 80 | |||
| location_region | 80 | 100% | 80 | |||
| longitude | 80 | 100% | 80 | |||
| timepoint_label | 80 | 100% | 80 |
- The impact of adverse childhood experiences on gut microbiota and markers of inflammation is mediated by obesity and depression. 2026 PMID 41651131 own_data
Archive description
Adverse childhood experiences (ACEs) are associated with poor health outcomes in adulthood including obesity, psychiatric symptoms, elevated levels of inflammatory markers, and suboptimal pregnancy outcomes. Female participants were recruited in the third trimester of pregnancy as part of a larger growth study of African-American infants. Participants were categorized as healthy weight or obese based on their early pregnancy BMI. They completed the Adverse Childhood Experiences Questionnaire (ACE-Q) and Center for Epidemiologic Studies Depression Scale (CES-D). Stool samples, blood, and dietary data were collected in the third trimester. Shotgun metagenomic sequencing was performed on DNA isolated from stool.
How this project entered the registry
Classified as human gut / stool / blood / tissue / internal fluids shotgun DNA metagenome of child and infant / toddler by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_unknown_no_evidence”
- body site study.title · “Childhood Experiences on gut microbiota and markers”
- body site study.description · “Depression Scale (CES-D). Stool samples, blood, and”
- body site study.description · “(CES-D). Stool samples, blood , and dietary”
- life stage study.title · “impact of Adverse Childhood Experiences on gut”
- life stage study.description · “Adverse childhood experiences (ACEs) are”
- life stage study.description · “study of African-American infants . Participants were”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN48713977 | antibiotic_exposure | no | R1 | 0.90 | biosample_attr | no |
| SAMN48713977 | bmi | 35.78 | R1 | 0.85 | biosample.attribute:prepreg_bmi | prepreg_bmi: 35.7799987792969 |
| SAMN48713977 | collection_date | 2016 | R1 | 0.90 | biosample.attribute:collection_date | 2016 |
| SAMN48713977 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA |
| SAMN48713977 | health_condition | obesity | R1 | 0.90 | biosample_attr | Obese |
| SAMN48713978 | health_condition | healthy_control | R1 | 0.85 | biosample.attribute:igram_group | igram_group: Lean |
| SAMN48713977 | health_condition_detail | Obese | R1 | 0.90 | sample.attr.igram_group | Obese |
| SAMN48713977 | latitude | 39.9560 | R1 | 0.90 | biosample.attribute:lat_lon | 39.956 N 75.193 W |
| SAMN48713977 | location_region | Pennsylvania | R1 | 0.60 | biosample.attribute:lat_lon | 39.956 N 75.193 W |
| SAMN48713977 | longitude | -75.1930 | R1 | 0.90 | biosample.attribute:lat_lon | 39.956 N 75.193 W |
| SAMN48713977 | subject_id | s100 | R1 | 0.85 | sample.attr.host_subject_id | s100 |
| SAMN48713977 | timepoint_label | 3T | R1 | 0.70 | sample.name_rule:alias | IG100.3T |
Sequencing
80 runs over 80 samples · mean 3.78 Gbp per run (median 3.80 Gbp, total 302.42 Gbp; 80 runs with a base count) · layout PAIRED 80 · platform ILLUMINA 80 · models Illumina HiSeq 2500 (80) · 99% of runs with a Sandpiper profile · first public 2025-05-28
Authors (0)
No author record.
Downloads
PRJNA1267192.csv.gz (3.3 KB) · parquet (74.5 KB) — all 80 samples, every field with route and confidence · PRJNA1267192_determinations.csv.gz (7.4 KB) — 880 evidence rows